Deepak Narayan Parchwani

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BACKGROUND Current treatment guidelines support the role of lifestyle modification, in terms of increasing the quantity and quality of physical activity to achieve target glycemia in patients with type 2 diabetes mellitus. OBJECTIVE To assess the effect of structured exercise training and unstructured physical activity interventions on glycemic control.(More)
Diabetic nephropathy is the leading cause of kidney disease in patients starting renal replacement therapy and affects ~30% of type 1 and type 2 diabetic patients. This review focuses on the progression and pathophysiological aspects of the condition. The natural history of diabetic nephropathy is characterized by specific renal morphological and functional(More)
BACKGROUND Diallelic [insertion/deletion (L/D)] polymorphism in the angiotensin-converting enzyme (ACE) gene has been reported inconsistently as being associated with risk of diabetic nephropathy (DN). OBJECTIVE To examine the three ACE poly-morphic variants in intron 16 for a possible role in modulating DN in T1DM patients from Kutch region, Gujarat. (More)
Type 2 diabetes is a complex and pleomorphic metabolic disorder arising from a complex interaction between genes and the environment. During the last decade there has been an outpouring of studies providing clues into the genetic architecture underlying type 2 diabetes mellitus. This review provides an overview of the genetics of type 2 diabetes in the(More)
Free radicals are potentially damaging to tissues, producing irreversible damage to biomolecules such as enzymes, proteins and membrane lipids. The current study was conducted to assess the concentration of malionaldehyde(MDA) as a marker of lipid peroxidation and total antioxidant status(TAS) in patients with active pulmonary tuberculosis and to examine(More)
Genetic polymorphism as described with angiotensin-converting enzyme gene has been proposed as a putative mediator of diabetic nephropathy. We substantiate the hypothesis that genetic variants of the ACE have significant impacts on diabetic nephropathy. To assess the possible association between the three ACE polymorphic variants and DN in an ethnically(More)
Background: Diabetic autonomic neuropathy is a serious and common complication of diabetes mellitus and in fact it is one of the most overlooked complications, thus very limited clinical and research data are available on early renal and cardiovascular autonomic complications in type 2 diabetes mellitus. Aims & Objective: To determine the possible(More)
Background: The acute effects of cigarette smoking in smokers include dyslipidemia and impaired insulin action that leads to abnormal glucose metabolism. Both dyslipidemia and insulin resistance are well-established major risk factor for cardiovascular disease. Aims & Objective: To ascertain the prevalence of several degrees of glucose abnormalities in(More)
The A/C transversion at 1166 of the angiotensin II Type 1 Receptor (AT1R) gene per se does not characterize any functional diversity but has been associated with expression of the AT1R, consequently molecular variants of the gene may modulate the possible risk of essential hypertension. The present study was performed to determine the genotypic frequency of(More)