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BACKGROUND Diallelic [insertion/deletion (L/D)] polymorphism in the angiotensin-converting enzyme (ACE) gene has been reported inconsistently as being associated with risk of diabetic nephropathy (DN). OBJECTIVE To examine the three ACE poly-morphic variants in intron 16 for a possible role in modulating DN in T1DM patients from Kutch region, Gujarat. (More)
Type 2 diabetes is a complex and pleomorphic metabolic disorder arising from a complex interaction between genes and the environment. During the last decade there has been an outpouring of studies providing clues into the genetic architecture underlying type 2 diabetes mellitus. This review provides an overview of the genetics of type 2 diabetes in the(More)
BACKGROUND Current treatment guidelines support the role of lifestyle modification, in terms of increasing the quantity and quality of physical activity to achieve target glycemia in patients with type 2 diabetes mellitus. OBJECTIVE To assess the effect of structured exercise training and unstructured physical activity interventions on glycemic control.(More)
Genetic polymorphism as described with angiotensin-converting enzyme gene has been proposed as a putative mediator of diabetic nephropathy. We substantiate the hypothesis that genetic variants of the ACE have significant impacts on diabetic nephropathy. To assess the possible association between the three ACE polymorphic variants and DN in an ethnically(More)
INTRODUCTION The musculocutaneous nerve (C5, C6, C7) is the nerve of the anterior compartment of the arm. It arises in the axilla as a branch of the lateral cord of the brachial plexus. It leaves the axilla by piercing the coracobrachialis muscle and enters the front of the arm. It courses down lying between the biceps brachii and brachialis muscle and(More)
Background: The acute effects of cigarette smoking in smokers include dyslipidemia and impaired insulin action that leads to abnormal glucose metabolism. Both dyslipidemia and insulin resistance are well-established major risk factor for cardiovascular disease. Aims & Objective: To ascertain the prevalence of several degrees of glucose abnormalities in(More)
Discovery of differences in the formation of triose phosphate intermediates (TPint) and methylglyoxal (MG) by cell metabolism between mouse strains with identical levels of hyperglycemia suggested prospective importance to diabetes complications. To assess the possible relevance of triose phosphates [glyceraldehyde-3-phosphate and dihydroxyacetone(More)
Several lines of experimental and clinical evidence have alluded a pivotal role of renin in blood pressure homeostasis and therefore a relevance of molecular variants of the renin gene and essential hypertension have been speculated. This study was designed to evaluate the pattern, alliance and risk of renin Mbo I (10631A>G; rs2368564) polymorphism at the(More)
The A/C transversion at 1166 of the angiotensin II Type 1 Receptor (AT1R) gene per se does not characterize any functional diversity but has been associated with expression of the AT1R, consequently molecular variants of the gene may modulate the possible risk of essential hypertension. The present study was performed to determine the genotypic frequency of(More)
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