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The purpose of this article is to explain the spread between spot rates on corporate and government bonds. We find that the spread can be explained in terms of three elements: (1) compensation for expected default of corporate bonds (2) compensation for state taxes since holders of corporate bonds pay state taxes while holders of government bonds do not,(More)
The Moody's KMV EDF (Expected Default Frequency) model of public firms is the pioneering implementation of a structural model that gives investors the ability to monitor credit risk across a broad range of firms. The release of the EDF 8.0 model represents a major recalibration of the model, which incorporates both a larger default dataset and improved(More)
BACKGROUND Colon cancer has been classically described by clinicopathologic features that permit the prediction of outcome only after surgical resection and staging. METHODS We performed an unsupervised analysis of microarray data from 326 colon cancers to identify the first principal component (PC1) of the most variable set of genes. PC1 deciphered two(More)
We have investigated the regulation of p27kip1, a cyclin-dependent kinase inhibitor, in BALB/c 3T3 cells during growth factor-stimulated transition from quiescence (G0) to a proliferative (G1) state. The level of p27kip1 protein falls dramatically after mitogenic stimulation and is accompanied by a decrease in cyclin E associated p27kip1, as well as a(More)
BACKGROUND Traumatic retroclival epidural hematoma is very rare and only a few cases are described in literature. All previous cases occurred in the pediatric population and were classically seen in pedestrians or cyclists hit by speeding motor vehicles. It is probable that horizontal articulation between the cranium and the atlas and ligamentous laxity at(More)
Antigen-specific lymphocytes are important in the immune response to viral infection. Peripheral blood mononuclear cells (PBMC) are traditionally used as a source of effector cells in most immunological studies. We described here the use of the bispecific monoclonal antibodies (BSMAB) anti CD3:CD8 (CD3,8) and anti CD3:CD4 (CD3,4B) to expand and selectively(More)
BACKGROUND Large flat polyps may be more amenable to endoscopic resection if an endoluminal method for full-thickness closure were available. OBJECTIVE Assessment of feasibility of endoluminal full-thickness closure. DESIGN Prospective, open-label, interventional study. SETTING Tertiary referral center. PATIENTS Patients referred to surgery for(More)