Deepa V. Pednekar

Learn More
CETP is a plasma glycoprotein that mediates the transfer of cholesterol ester (CE) from high-density lipoprotein (HDL) to apolipoprotein-B containing lipoproteins such as very low density lipoproteins (VLDL) and low density lipoprotein (LDL) with a balanced exchange of triglycerides. CETP thus plays a potential pro-atherogenic role by moving CE from HDL(More)
Oligomerizing to point-group symmetry, protein oligomers need to have the symmetry broken for biologically crucial functions, such as, allosteric regulation, enzyme catalysis, and so forth. In the making of symmetry, based on self assembly, and the breaking of symmetry, based on intermolecular interactions, proteins may manifest, like their other functions,(More)
Epidermal Growth Factor Receptor (EGFR) is among the growth factor receptor kinases that have been implicated in as being important in cancer. EGFR is over-expressed in numerous tumors including, those derived from the brain, lung, bladder, head and neck. Thus inhibitors of EGFR may serve as potential anticancer drugs. Herein we describe the 3D QSAR study(More)
Apparent electrostatics-defying clustering of arginines attributed as screening effect of solvent is in this study examined as a possible thermodynamic driving force in protein-protein interaction. A dataset of 266 protein dimers is found to have approximately 22% arginines mutually paired and approximately 17% pairs in interaction across interfaces and(More)
The Histamine H4 receptor is expressed mainly on eosinophils and mast cells and has been shown to be involved in the chemotaxis of both the cell types. The receptor is also implicated in the release of IL-16, from CD8+ T cells. This data indicate that the receptor may play a role in inflammatory process. Herein we describe 3D QSAR studies of non-imidazole(More)
  • 1