Declan Deasy

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Substantial increases in chromosome aberrations were induced in Chinese hamster ovary cells by medium made hyperosmotic with NaCl, KCl, sucrose, sorbitol or dimethyl methylphosphonate. The increases were associated with cytotoxicity but occurred in the range (e.g., 70% survival) commonly included in in vitro tests for 'genotoxicity'. The relation between(More)
OBJECTIVE To investigate the activity and local and systemic safety of the topical carbonic anhydrase inhibitor, dorzolamide hydrochloride. DESIGN Four-week, double-masked, randomized, placebo-controlled, parallel, three-center study. SETTING Referral centers. PATIENTS Forty-eight patients with bilateral open angle glaucoma or ocular hypertension and(More)
Topical carbonic anhydrase inhibitors MK-507 and sezolamide hydrochloride (previously known as MK-417) were compared in a double-masked, randomized, placebo-controlled study in 82 patients with bilateral primary open-angle glaucoma or ocular hypertension. MK-507 was given every 8 or 12 hours, sezolamide every 8 hours, or placebo every 8 or 12 hours for 4(More)
Ocular hypertensive patients were enrolled in a 6-week double-masked safety study of 2% MK-927 (27 patients), a topically active carbonic anhydrase inhibitor, administered bilaterally b.i.d.; 9 additional patients received 0.5% timolol as the control agent. Intraocular pressure (IOP) was measured weekly prior to a.m. drug administration; twelve hour diurnal(More)
NOTE: IN PROCESS. PDF of this Page SEMIC.EU Yearly Conference 2011 Community Participation in the SEMIC.EU Yearly Conference 2011 Purpose Talking Points May 19 2011 April 2011 Slides Spotfire Spotfire SEMIC.EU Yearly Conference: Speaker Action Points Invitation Conference Agenda Conference Brochure Welcome by Declan Deasy Rethinking Semantic(More)
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