Debra Easter

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Participating institutions: Abington Memorial Hospital, Abington, PA; Assaf Harofeh Medical Center, Zerifin, Israel; Cedars-Sinai Medical Center, Los Angeles, CA; Dakota Medical Center, Fargo, ND; Elmhurst Hospital, Chicago, IL; Fairfield Memorial Hospital, Fairfield, IL; Franklin Memorial Hospital, Farmington, ME; Grant Medical College, Bombay, India;(More)
The long-term efficacy and safety of sodium valproate and carbamazepine in adult outpatients with newly diagnosed primary generalised or partial and secondarily generalised seizures were compared in a randomised, open, multicentre study at 22 neurology outpatient clinics. Patients were randomised to oral sodium valproate (Epilim EC enteric coated 200 mg(More)
The long-term efficacy and adverse-event profiles of sodium valproate and carbamazepine in children with newly diagnosed primary generalised or partial epilepsy were compared at 63 outpatient clinics. Children with two or more generalised tonic-clonic or partial seizures in the previous six months were randomised to oral sodium valproate (N = 130) or oral(More)
Data presented in this study demonstrate that under normal physiological conditions milk phospholipids in the rat and the goat originate predominantly, if not totally, by de novo synthesis within the mammary gland. Evidence to support this has been obtained for the goat by measurement of P32-phosphate incorporation into milk phospholipids, and in the rat by(More)
This study explores the extent to which the theory of psychological ownership can be used to understand and design for slower consumption through two strategies: product longevity and access-<lb>based consumption. To do this we employ a qualitative study investigating objects kept, discarded and<lb>used by participants. We find that the theory is useful in(More)
The synthesis of monohydroxy- and dihydroxy-bifluranol, and of glucuronide and sulphate conjugates of bifluranol are described. Bifluranol administered orally to rats, ferrets and dogs at a dosage of 50 to 200 microgram kg-1 is mostly excreted in the faeces as unchanged bifluranol and bifluranol monosulphate, disulphate and monoglucuronide. The bifluranol(More)
The synthesis of bifluranol, a new fluorinated bibenzyl anti-androgen, and of 3H-labelled bifluranol is described. The absorption, distribution and excretion of bifluranol has been studied in mouse, rat, ferret and dog; it is readily absorbed following oral administration, but blood concentrations of the drug are low due to hepatic uptake and biliary(More)
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