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Plants have been historically used for diabetes treatment and related anti-inflammatory activity throughout the world; few of them have been validated by scientific criteria. Recently, a large diversity of animal models has been developed for better understanding the pathogenesis of diabetes mellitus and its underlying inflammatory mechanism and new drugs(More)
Despite its relatively poor efficacy, Bacillus Calmette-Guérin (BCG) has been used as a tuberculosis (TB) vaccine since its development in 1921. BCG induces robust T helper 1 (Th1) immune responses but, for many individuals, this is not sufficient for host resistance against Mycobacterium tuberculosis (M. tb) infection. Here we provide evidence that early(More)
This paper attempts to evaluate the anti-inflammatory potential and the possible mechanism of action of the leaf extracts and isolated compound(s) of Aerva sanguinolenta (Amaranthaceae), traditionally used in ailments related to inflammation. The anti-inflammatory activity of ethanol extract (ASE) was evaluated by acute, subacute and chronic models of(More)
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), resides and replicates within phagocytes and persists in susceptible hosts by modulating protective innate immune responses. Furthermore, M. tuberculosis promotes T helper 2 (Th2) immune responses by altering the balance of T cell polarizing cytokines in infected cells. However, cytokines(More)
Viral infections, particularly the infections caused by herpes simplex virus (HSV), represent one of the most serious public health concerns globally because of their devastating impact. The aim of this study was to evaluate the antiviral potential of methanolic crude extract of an ethnomedicine Mallotus peltatus, its active fraction and pure compound,(More)
Herpes genitalis, caused by HSV-2, is an incurable genital ulcerative disease transmitted by sexual intercourse. The virus establishes life-long latency in sacral root ganglia and reported to have synergistic relationship with HIV-1 transmission. Till date no effective vaccine is available, while the existing therapy frequently yielded drug resistance,(More)
Pedilanthus tithymaloides (PT) leaves are widely used in Indian medicine to treat inflammation and pain, but until recently no systematic study of these activities were reported. This study aimed to evaluate the antiinflammatory, antinociceptive, and antipyretic activity of the chloroform (CE) and methanol extract (ME) of PT leaves and its isolated(More)
Since time immemorial, in search for rescue for their disease, people looked for drugs in nature. The traditional use of medicinal plants can lead to the discovery of new potent botanical agents in the treatment of several diseases. Some 7000 natural compounds are currently used in modern medicine; most of these had been used for centuries by traditional(More)
Inflammation is part of self-limiting non-specific immune response, which occurs during bodily injury. In some disorders the inflammatory process becomes continuous, leading to the development of chronic inflammatory diseases including cardiovascular diseases, diabetes, cancer etc. Several Indian tribes used the bark of Odina wodier (OWB) for treating(More)
Since the dawn of human civilization, human beings have found remedies within their habitat and have adopted different therapeutic strategies depending upon climatic, phytogeographic, sociocultural, floral, and faunal characteristics. Traditional systems thus contain beliefs and practices in order to avoid, prevent, or avert ailments, which constitute(More)