Deborah Wallace

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'Racial' disparities among cancers, particularly of the breast and prostate, are something of a mystery. For the US, in the face of slavery and its sequelae, centuries of interbreeding has greatly leavened genetic differences between 'Blacks' and 'whites', but marked contrasts in disease prevalence and progression persist. 'Adjustment' for socioeconomic(More)
We argue that mesoscale ecosystem resilience shifts akin to sudden phase transitions in physical systems can entrain similarly punctuated events of gene expression on more rapid time scales, and, in part through such means, slower changes induced by selection pressure, triggering punctuated equilibrium Darwinian evolutionary transitions on geologic time(More)
  • Washington, Liam R O 'fallon, Frederick L Tyson, Allen Dearry, Barbara Israel, Loretta Jones +76 others
  • 2000
In the last ten years, traditional population-based biomedical research methods have been challenged due to limited community participation. Proponents for change explain that community participation, as an active partner in the research process, provides numerous benefits to research findings and public health intervention outcomes. In addition, community(More)
Generalized language-of-thought arguments appropriate to interacting cognitive modules permit exploration of how disease states interact with medical treatment. The interpen-etrating feedback between treatment and response creates a kind of idiotypic hall of mirrors generating a synergistic pattern of efficacy, treatment failure, adverse reactions, and(More)
In this study, the authors investigated the relation between reward and punishment sensitivity and adolescent substance use. The sample (N = 216; 130 girls, 85 boys) was drawn from high school and middle school students enrolled in a Midwestern suburban school district. Participants completed a substance use questionnaire and the Sensitivity to Punishment(More)
Glaucoma is an optic neuropathy that affects 60 million people worldwide. The main risk factor for glaucoma is increased intraocular pressure (IOP), this is currently the only target for treatment of glaucoma. However, some patients show disease progression despite well-controlled IOP. Another possible therapeutic target is the extracellular matrix (ECM)(More)
The central 'risk factor' for Alzheimer's disease (AD) is age. From first principles, we construct a mathematical model of protein folding and its in vivo regulation that gives this result in a natural manner. We extend the basic approach using topological information theory methods, and examine a case history of socially-induced premature aging in the(More)
We generalize a recent mathematical analysis of Bernard Baars' model of human consciousness to explore analogous, but far more complicated, phenomena of institutional cogni-tion. Individual consciousness is limited to a single, tunable, giant component of interacting cognitive modules, instantiating a Global Workspace. Human institutions, by contrast, seem(More)