Deborah Stuart

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The purpose of this study was to investigate the effects of music tempi on music preference, intrinsic motivation, and flow during long-duration exercise (approximately 26 min). Subjects (n = 29) selected the music of a single artist then walked at 70 % of maximum heart rate reserve (maxHRR) on a treadmill under three experimental conditions (medium tempi,(More)
After chronic hemisection at C3, stimulation of propriospinal fibers in the dorsal quadrant at Th 10 facilitated disynaptic PSPs from Ib afferents in hindlimb motoneurons. Recording from interneurons monosynaptically activated from group I muscle afferents, and of extracellular focal synaptic potentials around them, revealed monosynaptic EPSPs from long(More)
BACKGROUND Endothelin, via endothelin A receptors (ETA), exerts multiple pathologic effects that contribute to disease pathogenesis throughout the body. ETA antagonists ameliorate many experimental diseases and have been extensively utilized in clinical trials. The utility of ETA blockers has been greatly limited, however, by fluid retention, sometimes(More)
The role of intranephron angiotensinogen (AGT) in blood pressure (BP) regulation is not fully understood. Previous studies showed that proximal tubule-specific overexpression of AGT increases BP, whereas proximal tubule-specific deletion of AGT did not alter BP. The latter study may not have completely eliminated nephron AGT production; in addition, BP was(More)
Collecting duct (CD)-derived renin is involved in the hypertensive response to chronic angiotensin-II (Ang-II) administration. However, whether CD renin is involved in Ang-II independent hypertension is currently unknown. To begin to examine this, 12 week old male and female CD-specific renin knock out (KO) mice and their littermate controls were subjected(More)
Adenylyl cyclase (AC)-stimulated cAMP plays a key role in modulating transport and channel activity along the nephron. However, the role of individual adenylyl cyclase isoforms in such regulation is largely unknown. Since adenylyl cyclase 3 (AC3) is expressed throughout nephron, we investigated its role in the physiologic regulation of renal Na(+) and water(More)
Abstract Adenylyl cyclase (AC)-stimulated cAMP is a key mediator of collecting duct (CD) Na and water transport. AC isoforms 3, 4, and 6 are expressed in the CD. Our group demonstrated that AC6, but not AC3, is involved in regulating CD Na and water transport. However, the role of AC4 in such regulation remains unknown. Therefore, we generated mice with(More)
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