Deborah Sherwood

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Studies in mammalian cells have established the existence of at least three distinct mitogen-activated protein kinase (MAP kinase) signaling pathways that are activated by a variety of growth factors and/or environmental stressors. We determined whether physical exercise, a physiological stressor, and insulin, a metabolic stimulator and growth factor,(More)
To study the effects of contractile activity on mitogen-activated protein kinase (MAP kinase), p70 S6 kinase (p70(S6K)), and Akt kinase signaling in rat skeletal muscle, hindlimb muscles were contracted by electrical stimulation of the sciatic nerve for periods of 15 s to 60 min. Contraction resulted in a rapid and transient activation of Raf-1 and MAP(More)
OBJECTIVE This study tested the hypothesis that reductions in acute public-sector psychiatric inpatient capacity in a major urban area would be associated with negative impacts on patients and the community. METHODS The impact of two discrete service changes that reduced acute inpatient capacity by 50% in a single public-sector general hospital setting(More)
Direct sequence analysis of polymerase chain reaction-amplified DNA fragments from the large tegument protein (LTP) gene of human herpesvirus 6 (HHV-6) was performed with use of uncultured peripheral blood mononuclear cells (PBMCs) from four mother/infant pairs. In two cases, LTP gene sequences were identical in paired mother/infant specimens, thus(More)
  • Neal Maroney, Aris Protopapadakis, +6 authors Paul Zak
  • 1999
The positive relation of returns with Book-to-Market ratio (BE/ME) and their negative relation with Market Value (MVE) remains strong under a general stochastic discount function (SDF) that does not depend on a specific asset pricing model and avoids potentially serious simultaneity biases inherent in the Fama and French three-factor model. However, we find(More)
Using a data sample corresponding to an integrated luminosity of 342 fb(-1) collected with the BABAR detector at the SLAC PEP-II electron-positron storage ring operating at a center-of-mass energy near 10.58 GeV, we measure B(tau(-)--> pi(-)pi(-)pi+nu(tau)(ex.K(S0))=(8.83+/-0.01+/-0.13)%, B(tau(-) -->K(-)pi(-)pi+nu tau(ex.K(S0))=(0.273+/-0.002+/-0.009)%,(More)
New Zealand white rabbits were fed a diet enriched with cholesterol (0.25%) for 4 months. At that time, the aortae and coronary vessels of the cholesterol-fed rabbits were extensively covered with atherosclerotic lesions while those of age-matched control rabbits were normal. Langendorff-perfused hearts from the rabbits were compared for their ability to(More)
We observe a new D_{s} meson with mass (2856.6+/-1.5_{stat}+/-5.0_{syst}) MeV/c;{2} and width (48+/-7_{stat}+/-10_{syst}) MeV/c;{2} decaying into D0K+ and D;{+}K_{S};{0}. In the same mass distributions, we also observe a broad structure with mass (2688+/-4_{stat}+/-3_{syst}) MeV/c;{2} and width (112+/-7_{stat}+/-36_{syst}) MeV/c;{2}. To obtain this result,(More)
One consistent racial difference in mineral homeostasis is increased efficiency of renal calcium conservation in blacks which could account, in part, for differences in bone density and fracture risk. Since parathyroid hormone (PTH) is the major regulator of calcium homeostasis, we investigated its secretion in black and white women in response to(More)
B. Aubert, M. Bona, D. Boutigny, F. Couderc, Y. Karyotakis, J. P. Lees, V. Poireau, V. Tisserand, A. Zghiche, E. Grauges, A. Palano, J. C. Chen, N. D. Qi, G. Rong, P. Wang, Y. S. Zhu, G. Eigen, I. Ofte, B. Stugu, G. S. Abrams, M. Battaglia, D. N. Brown, J. Button-Shafer, R. N. Cahn, E. Charles, M. S. Gill, Y. Groysman, R. G. Jacobsen, J. A. Kadyk, L. T.(More)