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The evolution, synthesis, and biological activity of a novel series of 5-HT(2C) receptor inverse agonists are reported. Biarylcarbamoylindolines have been identified with excellent 5-HT(2C) affinity and selectivity over 5-HT(2A) receptors. In addition, (pyridyloxypyridyl)carbamoylindolines have been discovered with additional selectivity over the closely(More)
Chronic feeding of methyl-donor (methionine, choline, folic acid, and vitamin B12) deficient diet induces hepatocellular carcinoma formation in rats. Previous studies have shown that promoter CpG islands in various cancer-related genes are aberrantly methylated in this model. Moreover, the global genome in methyl-donor-deficient diet fed rats contains a(More)
There is morphological and biochemical evidence that insulin is internalized in hepatocytes. The present study was designed to investigate the fate of the insulin receptor itself, subsequently to the initial binding step of the hormone to the hepatocyte plasma membrane. The insulin receptor was labeled with a 125I-photoreactive insulin analogue(More)
The first step of insulin's many cellular functions is specific binding to receptors on the plasma membrane of target cells. The subsequent molecular basis of insulin action, particularly the coupling mechanism(s) involved in transmitting the biological message, remains largely unknown. Our approach to the problem centres on the application of a series of(More)
  • BEEN ADDRESSED, Deborah Saunders, Carol Flango, Dan Straub, Joan Cochet, Toni Grainer
  • 2011
ii Acknowledgments First of all, I would like to thank my Director Carol Flango for giving me the opportunity to participate in this program. Thanks also to my advisor and fearless leader, Dan Straub who helped to focus my study and keep me on track. To Joan Cochet and her team of interns, thank you for finding ―just one more article‖ for me again and(More)
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