Deborah S Kamal

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Glaucomatous optic neuropathy, an important neurodegenerative condition and the commonest optic neuropathy in humans, is the leading cause of irreversible blindness worldwide. Its prevalence and incidence increase exponentially with ageing and raised intraocular pressure (IOP). Using glaucomatous optic neuropathy as an exemplar for neurodegeneration, this(More)
AIM To determine if global and segmental changes in optic disc parameters of sequential Heidelberg retina tomograph (HRT) images develop in individual ocular hypertensive (OHT) patients without white on white visual field defects. METHODS Patients and normal controls were recruited from a prospective ocular hypertension treatment trial. The subject groups(More)
AIMS The development of imaging and measurement techniques has brought the prospect of greater objectivity in the measurement of optic disc features, and therefore better agreement between observers. The purpose of this study was to quantify and compare the variation between observers using two measurement devices. METHODS Optic disc photographs and(More)
AIMS To evaluate long-term outcomes and complications of trabeculectomy for normal tension glaucoma (NTG) with contemporary surgical techniques. METHODS Retrospective consecutive, non-comparative case series of 131 eyes of 98 patients undergoing trabeculectomy between 2007 and 2013 in a dedicated NTG clinic. Data collected during routine clinical care(More)
AIM To determine whether analysis of sequential optic disc images obtained with the Heidelberg retina tomograph (HRT) is able to demonstrate optic disc change before the development of reproducible field defects in a group of ocular hypertensive (OHT) patients converting to early glaucoma. METHODS Two groups were analysed: (1) 13 eyes of 13 OHT patients(More)
Normal tension glaucoma (NTG) remains a diYcult diagnosis for the ophthalmologist who favours the argument that raised intraocular pressure (IOP) is essential for the diagnosis of primary open angle glaucoma (POAG). The concept of NTG challenges us to distinguish between pressure dependent and pressure independent causal factors. The purpose of this review(More)
Purpose. To determine whether treatment with betaxolol can delay or prevent the conversion from ocular hypertension to early glaucoma on the basis of visual field criteria, by means of a prospective, randomised, placebo-controlled trial. Methods. Three hundred and fifty-six ocular hypertensives were randomized to treatment with either betaxolol drops or(More)
We report an observational study, based on the examination of 319 medical records, identifying the proportion of patients whose driving status was documented on the first and subsequent glaucoma clinic visits. We also established the proportion of patients with documented Driving and Vehicle Licencing Agency (DVLA)-related advice when they did not meet(More)
PURPOSE To map the 3-dimensional (3D) strain of the optic nerve head (ONH) in vivo after intraocular pressure (IOP) lowering by trabeculectomy (TE) and to establish associations between ONH strain and retinal sensitivity. DESIGN Observational case series. PARTICIPANTS Nine patients with primary open-angle glaucoma (POAG) and 3 normal controls. METHODS(More)
AIM To examine the level of agreement between clinicians in assessing progressive deterioration in visual field series using two different methods of analysis. METHODS Each visual field series satisfied the following criteria: more than 19 reliable fields, patient age over 40 years, macular threshold at least 30 dB. The first three fields in each series(More)