Deborah P Saunders

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An aerodynamic shape optimization method that treats the design of complex aircraft configurations subject to high fidelity CFD, geometric constraints and multiple design points is described. The design process will be greatly accelerated through the use of both control theory and distributed memory computer architectures. Control theory is employed to(More)
This work describes the implementation of optimization techniques based on control theory for complex aircraft configurations. Here control theory is employed to derive the adjoint differential equations, the solution of which allows for a drastic reduction in computational costs over previous design methods. Design formulations for both potential flows and(More)
This work provides a systematic review of the literature from January 2003 to April 2014 pertaining to the incidence, pathophysiology, diagnosis, and treatment of osteonecrosis of the jaw (ONJ), and offers recommendations for its management based on multidisciplinary international consensus. ONJ is associated with oncology-dose parenteral antiresorptive(More)
Chronic feeding of methyl-donor (methionine, choline, folic acid, and vitamin B12) deficient diet induces hepatocellular carcinoma formation in rats. Previous studies have shown that promoter CpG islands in various cancer-related genes are aberrantly methylated in this model. Moreover, the global genome in methyl-donor-deficient diet fed rats contains a(More)
PURPOSE To examine normal human corneal epithelium in vivo and in vitro for expression and status of plasniinogcn activ:ltor inhibitor type 2 (PAI-2). METHODS Normal hiuman corneas were prepared for frozen sections and for culture of corneal keratinocytes. PAI-2 was analyzed by immunohistochemistry and western blot analysis uising antibodies that(More)
The focus of CFD applications has shifted to aerodynamic design. This shift has been mainly motivated by the availability of high performance computing platforms and by the development of new and efficient analysis and design algorithms. In particular automatic design procedures, which use CFD combined with gradient-based optimization techniques, have had a(More)
ii Acknowledgments First of all, I would like to thank my Director Carol Flango for giving me the opportunity to participate in this program. Thanks also to my advisor and fearless leader, Dan Straub who helped to focus my study and keep me on track. To Joan Cochet and her team of interns, thank you for finding ―just one more article‖ for me again and(More)
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