Deborah Leibham

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BACKGROUND . Modern biological research is highly dependent upon recombinant DNA technology. Conventional cloning methods are time-consuming and lack uniformity. Thus, biological research is in great need of new techniques to rapidly, systematically and uniformly manipulate the large sets of genes currently available from genome projects. RESULTS . We(More)
The octamer motif is a common cis-acting regulatory element that functions in the transcriptional control regions of diverse genes and in viral origins of replication. The ability of a consensus octamer motif to stimulate transcription of a histone H2B promoter in frog oocytes suggests that oocytes contain a transcriptionally active octamer-binding(More)
Members of the MyoD family of helix-loop-helix proteins control expression of the muscle phenotype by regulating the activity of subordinate genes. To investigate processes that control the expression of myogenic factors and regulate the establishment and maintenance of the skeletal muscle phenotype, we have analyzed sequences necessary for transcription of(More)
Members of the MEF2 family of DNA binding proteins interact with a set of AT-rich sequences commonly found in the promoters and enhancers of muscle-specific genes. We have shown that a MEF2 binding site precisely overlaps the TFIID binding site (TATA box) in the Xenopus MyoDa (XMyoDa) promoter and appears to play an important role in muscle-specific(More)
References and Notes 1. K. W. Kinzler and B. Vogelstein, Nature 386, 761 (1997). 2. K. Savitsky et al., Science 268, 1749 (1995). 3. P. Athma, R. Rappaport, M. Swift, Cancer Genet. Cytogenet. 92, 130 (1996); N. Janin et al., Br. J. Cancer 80, 1042 (1999). 4. R. Wooster et al., Nature 378, 789 (1995); S. V. Tavtigian et al., Nature Genet. 12, 333 (1996). 5.(More)
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