Deborah L. Sodickson

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GABA and the GABAB receptor agonist baclofen activated a potassium conductance in acutely dissociated hippocampal CA3 neurons. Baclofen-activated current required internal GTP, was purely potassium selective, and showed strong inward rectification. As with acetylcholine-activated current in atrial myocytes, external Cs+ blocked inward but not outward(More)
We characterized potassium current activated by G-protein-coupled receptors in acutely dissociated hippocampal CA3 neurons. Agonists for serotonin, adenosine, and somatostatin receptors reliably activated a potassium-selective conductance that was inwardly rectifying and that was blocked by 1 mM external Ba2+. The conductance had identical properties to(More)
Grief, Gabriela J., Deborah L. Sodickson, Bruce P. Bean, Eva J. Neer, and Ulrike Mende. Altered regulation of potassium and calcium channels by GABAB and adenosine receptors in hippocampal neurons from mice lacking Gao. J. Neurophysiol. 83: 1010–1018, 2000. To examine the role of Go in modulation of ion channels by neurotransmitter receptors, we(More)
To examine the role of G(o) in modulation of ion channels by neurotransmitter receptors, we characterized modulation of ionic currents in hippocampal CA3 neurons from mice lacking both isoforms of Galpha(o). In CA3 neurons from Galpha(o)(-/-) mice, 2-chloro-adenosine and the GABA(B)-receptor agonist baclofen activated inwardly rectifying K(+) currents and(More)
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