Deborah L. Bennett

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Capacitative calcium entry is a major pathway through which intracellular calcium stores are refilled after stimulation. It has been suggested that the protein encoded by the transient receptor potential (trp) gene expressed in Drosophila photoreceptors may be homologous with capacitative calcium entry channels. Expression of the trp gene product in Xenopus(More)
Capacitative Ca2+ entry (CCE) is a universal mechanism for refilling intracellular Ca2+ stores in electrically non-excitable cells. The situation in excitable cells is less clear, however, since they may rely on other entry mechanisms for Ca2+-store refilling. In the present study we investigated CCE in intact PC12 cells, using acetylcholine to bring about(More)
A variety of models on the interaction between glucose and insulin have been suggested over the last 50 years. One, developed by Sturis et al. [19], and consisting of six nonlinear ordinary differential equations, has been widely accepted. However, the model has the disadvantage of containing auxiliary variables which have no clinical interpretation. In(More)
The way of the Grand unification of all interactions and the role of su-persymmetry in GUTs are the problems of paramount importance in the contemporary elementary particle physics. However, at present time experiment doesn't indicate any manifestation of the Supersymmetry (see reviews [1-3]). In this connection, the Anti–Grand Unification Theory (AGUT) was(More)
Stimulation of cells with Ca(2+)-mobilizing hormones often leads to the generation of temporally and spatially complex changes in the intracellular Ca2+ ion concentration ([Ca2+]i). To understand the mechanisms regulating Ca2+ release from intracellular stores more clearly, we investigated the ability of histamine to release Ca2+ stores under different(More)
We report the sequence, structure and distribution of a novel transient receptor potential (trp) homologue from Xenopus, Xtrp, determined by screening an oocyte cDNA library. On the basis of sequence similarity and predicted structure, Xtrp appears to be a homologue of mammalian trp1 proteins. Two polyclonal antibodies raised against distinct regions of the(More)