Deborah Kaplan

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Nuclear orphan receptor TLX (Drosophila tailless homolog) is essential for the maintenance of neural stem/progenitor cell self-renewal, but its role in neuroblastoma (NB) is not well understood. Here, we show that TLX is essential for the formation of tumor spheres in three different NB cell lines, when grown in neural stem cell media. We demonstrate that(More)
In this study we have addressed the question of how activation and inhibition of human NK cells is regulated by the expression level of MHC class I protein on target cells. Using target cell transfectants sorted to stably express different levels of the MHC class I protein HLA-Cw6, we show that induction of degranulation and that of IFN-γ secretion are not(More)
Despite high profile discussions of user-centered design in the CHI community, until recently a substantial population of users has been largely ignored. Users who have restricted or no use of hands, eyes, ears, or voice due to environment, task context, repetitive strain injury, or disability constitute a diverse and significant user population, but these(More)
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