Deborah Kaplan

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In this study we have addressed the question of how activation and inhibition of human NK cells is regulated by the expression level of MHC class I protein on target cells. Using target cell transfectants sorted to stably express different levels of the MHC class I protein HLA-Cw6, we show that induction of degranulation and that of IFN-γ secretion are not(More)
Lyn, an Src-family protein tyrosine kinase expressed in B lymphocytes, contributes to initiation of BCR signaling and is also responsible for feedback inhibition of BCR signaling. Lyn-deficient mice have a decreased number of follicular B cells and also spontaneously develop a lupus-like autoimmunity. We used flow cytometric analysis, BrdU labeling and our(More)
Despite high profile discussions of user-centered design in the CHI community, until recently a substantial population of users has been largely ignored. Users who have restricted or no use of hands, eyes, ears, or voice due to environment, task context, repetitive strain injury, or disability constitute a diverse and significant user population, but these(More)
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