Deborah K. Weisser

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A fundamental tool for exploring the structure of a long DNA sequence is to construct a \library" consisting of many cloned fragments of the sequence. Each fragment can be replicated indeenitely and then \\ngerprinted" to obtain partial information about its structure. A common type of ngerprinting is restriction ngerprinting, in which an enzyme called a(More)
The goal of physical mapping of the genome is to reconstruct a strand of DNA given a collection of overlapping fragments, or clones, from the strand. We present several algorithms to infer how the clones overlap, given data about each clone. We focus on data used to map human chromosomes 21 and Y, in which relatively short substrings, or probes, are(More)
Protein sequence data is abundant, yet derivation of structural features from sequence alone is generally restricted to prediction of domain architecture, secondary structure elements and motifs. Precise feature boundaries cannot be determined reliably, and it is unknown to what extent these features constitute fundamental building blocks of protein(More)
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