Deborah J. Olson

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The performance of 4 seed-caching corvid species was tested using 2 different operant nonmatching tasks. These species differ in their dependence on stored food, and differences in spatial memory tests have been correlated with better performance by the more cache-dependent species. Acquisition and retention of a color non-matching-to-sample task was tested(More)
Pigeons learned a delayed-alteration (DA) task in a T-maze. Very few trials were needed prior to accurate performance. Similarly, after little training the birds performed accurately with delays of 8-16 min. End-of-delay cues, possibly provided by the experimenter, response-based cues, and intramaze cues were all experimentally examined and rejected as(More)
An operant nonmatching to sample procedure was used to compare the spatial memory abilities of 3 avian species. A trial consisted of the presentation of a spatially defined sample, a delay interval, and a 2-choice test during which the correct location was the new location. A single spatial location served as the sample in Experiment 1. The delay interval(More)
Four seed-caching corvid species were tested in an open-room analog of the radial-arm maze. During Experiment 1, the species more dependent on stored food. Clark's nutcrackers (Nucifraga columbiana) and pinyon jays (Gymnorhinus cyanocephalus), acquired the task more quickly and to higher accuracy levels than either scrub jays (Aphelocoma coerulescens) or(More)
Treatment with aminoglycosides is known to cause irreversible hearing loss, typically affecting higher-frequency hearing first and progressing to lower frequencies. Standardized methodology has not been developed for early detection of ototoxicity. Serial conventional (0.25-8 kHz) and high-frequency (9-20 kHz) hearing threshold monitoring was done(More)
The disruption of the normal expression of wnt-5a in cell lines and in tumors is becoming increasingly recognized as important in cell transformation and tumorigenesis. For example, in endometrial cancer wnt-5a is downregulated compared to normal tissue. Our laboratory has recently found that the ectopic expression of wnt-5a in human RCC23 renal carcinoma(More)
Polycomb (Pc) is involved in the stable and heritable repression of homeotic gene activity during Drosophila development. Here, we report the identification of a novel human Pc homolog, hPc2. This gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins(More)
Cisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy to detect cisplatin-induced ototoxicity is needed. Serial(More)
A Macintosh computer-based audiometer (Virtual 320) was evaluated for reliability and validity of high-frequency (8-20 kHz) thresholds by comparison with a well documented laboratory high-frequency evaluation system (PARVA-HF). High-frequency earphones originally provided with the V320 for high-frequency testing required modification to improve reliability(More)
Subjects receiving treatment with ototoxic agents were evaluated concurrently with conventional and high-frequency (> or = 8 kHz) behavioral threshold measures and with ABR to click and to 8, 10, 12, and 14 kHz tone-burst stimuli. Behavioral threshold data revealed ototoxic change in 51 percent of ears evaluated. Of these ears demonstrating behavioral(More)