Deborah F. Sweeney

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PURPOSE To compare accommodative facility in eyes with myopia to that in eyes with emmetropia or hyperopia and to determine whether accommodative facility can be used to predict an association with myopia. METHODS In the Sydney Myopia Study, year-1 school children (6.7 +/- 0.4 years) were assessed for accommodative facility at distance (3 m) and near (33(More)
PURPOSE Fibronectin plays an important role in corneal healing and has been detected previously in the tear film. To investigate the levels of fibronectin in normal human tears, the authors measured and compared fibronectin concentration in open-eye, closed-eye, and reflex tear fluid. The origin of fibronectin in the tear film was investigated by comparing(More)
The effects of long-term extended wear of soft contact lenses on the human cornea were determined by examining 27 patients who had worn a high water content hydrogel contact lens in 1 eye only for an average of 62 +/- 29 months (mean +/- SD). The other eye, which was either emmetropic or amblyopic, acted as a control. The lens-wearing eye showed a 14.8%(More)
PURPOSE To determine whether intolerance to contact lens wear is attributable to clinical or protein characteristics of the tear film. METHODS Thirty-eight subjects participated; 20 were successful contact lens wearers and 18 had discontinued contact lens wear because of discomfort. Baseline tear film (no lens wear) was analyzed with a range of clinical(More)
One eye of each of eight subjects was exposed to gases containing oxygen concentrations of 1.0%, 2.5%, 4.9%, 7.5%, 10.1%, and 21.4% (oxygen partial pressures ranging from 8 to 158 mmHg) for 8 hr. The precorneal oxygen concentration required to avoid corneal edema for the group as a whole was 10.1% (an oxygen tension of 74 mmHg). There was considerable(More)
PURPOSE This study examined the potential of a synthetic polymer to support stable epithelial growth when implanted in the feline cornea. METHODS A perfluoropolyether-based polymer was cast into lenticules that were coated with collagen I and implanted in four feline corneas. Epithelial growth onto the lenticules was monitored clinically for 6 weeks,(More)
PURPOSE This study investigated ocular surface components that contribute to matrix-metalloproteinase (MMP)-2 and MMP-9 found in tears following corneal epithelial wounding. METHODS Laboratory short-haired cats underwent corneal epithelial debridement in one randomly chosen eye (n = 18). Eye-flush tears were collected at baseline and during various(More)
PURPOSE To assess the long-term biocompatibility and optical clarity of a perfluoropolyether (PFPE) polymer as a corneal inlay. METHODS A 4-mm-diameter PFPE inlay was implanted under a microkeratome flap in the corneas of rabbits (n = 16) and maintained for predetermined time points of 6, 12, or 24 months. These were compared with normal (n = 3) and(More)
The ocular characteristics and responses were examined in patients who had undergone extracapsular cataract extraction (ECCE), intracapsular cataract extraction (ICCE) and penetrating keratoplasty (PKP) in one eye only. In each of the three groups, corneal sensitivity (the inverse of corneal touch threshold), oxygen uptake rate, and endothelial cell density(More)
PURPOSE To investigate the effect of a range of biological coatings on corneal epithelialization of a synthetic polymer surface in vivo. METHODS Eight diverse biological factors (collagen I, collagen III, collagen IV, laminin, fibronectin, endothelial extracellular matrix, hyaluronic acid, and chondroitin sulfate) were coated individually onto the surface(More)