Deborah E. Zetes

Learn More
Current hypotheses regarding mechanotransduction rely upon motion of the stereocilia relative to the apical surface of the hair cell. The viscosity of the surrounding endolymphatic fluid will, however, attenuate stereocilia motion at higher frequencies of excitation. To investigate stereocilia motion for physiologically reasonable deflections and(More)
In sensory hair cells of the cochlea, deflection of the stereociliary bundle results in direct mechanical gating of mechanoelectrical transduction channels, a function generally attributed to the tip link running between the tips of short stereocilia and the sides of adjacent taller ones. However, immunocytochemical experiments indicate that the channels(More)
The mechanical properties of the mammalian organ of Corti determine its sensitivity to sound frequency and intensity, and the structure of supporting cells changes progressively with frequency along the cochlea. From the apex (low frequency) to the base (high frequency) of the guinea pig cochlea inner pillar cells decrease in length incrementally from 75-55(More)
  • 1