Deborah C. Hizume

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The spectral analysis of crackles sounds has been carried out based on the assumption that they are stationary signals, and the majority of the work on the crackles was accomplished before the publication of the Computerized Respiratory Sound Analysis (CORSA) guidelines. This works characterizes crackles acquired from patients with fibrosis, heart failure,(More)
It has recently been suggested that regular exercise reduces lung function decline and risk of chronic obstructive pulmonary disease (COPD) among active smokers; however, the mechanisms involved in this effect remain poorly understood. The present study evaluated the effects of regular exercise training in an experimental mouse model of chronic cigarette(More)
We evaluated the effects of cigarette smoke (CS) on lung inflammation and remodeling in a model of ovalbumin (OVA)-sensitized and OVA-challenged mice. Male BALB/c mice were divided into 4 groups: non-sensitized and air-exposed (control); non-sensitized and exposed to cigarette smoke (CS), sensitized and air-exposed (OVA) (50 μg+OVA 1% 3 times/week for 3(More)
Lung sounds recorded on the chest are attenuated by the thorax and thorax-microphone interface. In order to recover waveforms similar to the ones generated within the lungs, this paper equalizes crackle sounds recorded on the chest. From an experiment in which eight subjects (seven men) took part, an estimation of the channel (thorax and thorax-microphone(More)
UNLABELLED Our purpose in this study was to access the pulmonary effects of mechanical ventilation with positive end-expiratory pressure (PEEP; 10 cmH2O) or without PEEP (zero PEEP-ZEEP) in a rat model of acute myocardial infarction that resulted in hypotension but not in pulmonary congestion. METHODS Wistar rats were anesthetized (1.5% isoflurane) and(More)
PURPOSE Exposure to diesel exhaust particles (DEP) results in lung inflammation. Regular aerobic exercise improves the inflammatory status in different pulmonary diseases. However, the effects of long-term aerobic exercise on the pulmonary response to DEP have not been investigated. The present study evaluated the effect of aerobic conditioning on the(More)
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