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  • Patricia A. Bresnahan, Wes Yonemoto, Sharon Ferrell, Debora Williams-Herman, Romas Geleziunas, Warner C. Greene
  • Biology, Medicine
  • Current Biology
  • 1998 (First Published: 1 November 1998)
  • Human immunodeficiency virus 1 (HIV-1) Nef downregulates surface expression of CD4, an integral component of the functional HIV receptor complex, through accelerated endocytosis of surface receptorsContinue Reading
  • Rosario Arechavaleta, Thomas Seck, +6 authors Barry J. Goldstein
  • Medicine
  • Diabetes, obesity & metabolism
  • 2011 (First Published: 1 February 2011)
  • AIM to evaluate the efficacy and safety of adding sitagliptin or glimepiride to the treatment regimen of patients with type 2 diabetes mellitus and inadequate glycaemic control on metforminContinue Reading
  • Elizabeth M. Migoya, Raynald Bergeron, +19 authors Ranabir Sinharoy
  • Chemistry, Medicine
  • Clinical pharmacology and therapeutics
  • 2010 (First Published: 1 December 2010)
  • The aim of the study was to investigate the effects of a dipeptidyl peptidase-4 (DPP-4) inhibitor, of metformin, and of the combination of the two agents, on incretin hormone concentrations. ActiveContinue Reading
  • Debora Williams-Herman, Samuel S Engel, +7 authors Barry J. Goldstein
  • Medicine
  • BMC endocrine disorders
  • 2010 (First Published: 1 December 2010)
  • BackgroundIn a previous pooled analysis of 12 double-blind clinical studies that included data on 6,139 patients with type 2 diabetes, treatment with sitagliptin, a dipeptidyl peptidase-4 (DPP-4)Continue Reading
  • Debora Williams-Herman, Jacquett R Johnson, +4 authors John M. Amatruda
  • Medicine
  • Diabetes, obesity & metabolism
  • 2010 (First Published: 30 March 2010)
  • AIM To assess the 104-week efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy in patients with type 2 diabetes and inadequate glycaemic controlContinue Reading
  • Nir Barzilai, Hua Jun Guo, +8 authors Helmut Steinberg
  • Medicine
  • Current medical research and opinion
  • 2011 (First Published: 1 May 2011)
  • OBJECTIVE Type 2 diabetes in the elderly is an important and insufficiently studied public health problem. This study evaluated sitagliptin monotherapy in patients with type 2 diabetes aged ≥ 65Continue Reading
  • Lei Xu, Chiara Dalla Man, +5 authors Peter P. Stein
  • Medicine
  • Diabetes, obesity & metabolism
  • 2008 (First Published: 12 May 2008)
  • PURPOSE The purpose of this exploratory analysis was to assess the effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on pancreatic beta-cell function using a model-based analysis. METHODSContinue Reading