Debora Bade

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The centromere is a specialized chromatin region that functions as foundation for kinetochore formation in mitosis. As a result, it is essential for proper chromosome segregation and the maintenance of genomic integrity. The centromere is defined epigeneti cally by the presence of the histone H3 variant CenH3 that is exclusively found within centromeric(More)
Centromeres are defined by the presence of the histone H3 variant CENP-A in a subset of centromeric nucleosomes. CENP-A deposition to centromeres depends on a specialized loading factor from yeast to humans that is called CAL1 in Drosophila. Here, we show that CAL1 directly interacts with RDX, an adaptor for CUL3-mediated ubiquitylation. However, CAL1 is(More)
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