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Mechanomics: an emerging field between biology and biomechanics
Cells sense various in vivo mechanical stimuli, which initiate downstream signaling to mechanical forces. While a body of evidences is presented on the impact of limited mechanical regulators in pastExpand
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  • Open Access
Distinct Binding Affinities of Mac-1 and LFA-1 in Neutrophil Activation
Macrophage-1 Ag (Mac-1) and lymphocyte function-associated Ag-1 (LFA-1), two β2 integrins expressed on neutrophils (PMNs), mediate PMN recruitment cascade by binding to intercellular adhesiveExpand
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  • Open Access
Conformational Stability Analyses of Alpha Subunit I Domain of LFA-1 and Mac-1
β2 integrin of lymphocyte function-associated antigen-1 (LFA-1) or macrophage-1 antigen (Mac-1) binds to their common ligand of intercellular adhesion molecule-1 (ICAM-1) and mediatesExpand
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Salt bridge interactions within the β2 integrin α7 helix mediate force‐induced binding and shear resistance ability
The functional performance of the αI domain α7 helix in β2 integrin activation depends on the allostery of the α7 helix, which axially slides down; therefore, it is critical to elucidate what factorsExpand
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Polymer inclusion membrane (PIM) containing ionic liquid as a proton blocker to improve waste acid recovery efficiency in electrodialysis process
Abstract Industrial activities generate large amounts of low-concentration waste acids. This is not only a waste of resources, but also a hazard to the environment. Waste acid recovery andExpand
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Distinct Kinetics Features of LFA-1 and Mac-1 in Neutrophil Activation
LFA-1 and Mac-1, two β 2 integrin members constitutively expressed on neutrophils, mediate leukocyte recruitment cascade by binding to the same ligand of ICAM-1. The slow rolling and firm adhesion ofExpand
Contribution of the CR Domain to P-Selectin Lectin Domain Allostery by Regulating the Orientation of the EGF Domain
The allostery of P-selectin has been studied extensively with a focus on the Lec and EGF domains, whereas the contribution of the CR domain remains unclear. Here, molecular dynamics simulations (MDS)Expand
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  • Open Access