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Prion protein polymorphisms in white-tailed deer influence susceptibility to chronic wasting disease.
The primary sequence of the prion protein affects susceptibility to transmissible spongiform encephalopathies, or prion diseases, in mice, sheep and humans. The Prnp gene sequence of free-ranging,Expand
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Impact of frequency of denture cleaning on microbial and clinical parameters – a bench to chairside approach
ABSTRACT Objective: Robust scientific and clinical evidence of how to appropriately manage denture plaque is lacking. This two-part study (i) developed an in vitro model of denture plaque removal,Expand
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MtDNA point mutations are associated with deletion mutations in aged rat
The age-dependent accumulation of point mutations in the control region of human mtDNA has been suggested to contribute to aging processes. We investigated whether mtDNA point mutations accumulate toExpand
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Toll‐like receptor‐mediated immune response inhibits prion propagation
Prion diseases are progressive neurodegenerative disorders affecting humans and various mammals. The prominent neuropathological change in prion diseases is neuroinflammation characterized byExpand
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Comment on: “Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging. Cells 2020, 9, 197”
"The main conclusions are that the ageing atrophy begins as early as around 25 years of age and thereafter accelerates and, for this muscle, is caused mainly by a loss of fibers and to a lesserExpand
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Replication of prions in differentiated muscle cells
We have demonstrated that prions accumulate to high levels in non-proliferative C2C12 myotubes. C2C12 cells replicate as myoblasts but can be differentiated into myotubes. Earlier studies indicatedExpand
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HEAD-TO-HEAD DEBATE ON THE MITOCHONDRIAL THEORY OF AGING Rebuttal to Jacobs: The mitochondrial theory of aging: alive and well
We agree with much of what Dr Jacobs argues but would like to comment on some of his statements. He makes many valid comments, comments that were very relevant 4‐5 years ago. Studies based on tissueExpand
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Long-Term Incubation PrPCWD with Soils Affects Prion Recovery but Not Infectivity
Chronic wasting disease (CWD) is a contagious prion disease of cervids. The infectious agent is shed from animals at the preclinical and clinical stages of disease where it persists in theExpand
Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms
Chronic wasting disease (CWD) is caused by an unknown spectrum of prions and has become enzootic in populations of cervid species that express cellular prion protein (PrPC) molecules varying in aminoExpand