Learn More
The formation of an atherosclerotic lesion is mediated by lipid-laden macrophages (foam cells), which also establish chronic inflammation associated with lesion progression. The peroxisome proliferator-activated receptor (PPAR) gamma promotes lipid uptake and efflux in these atherogenic cells. In contrast, we found that the closely related receptor(More)
BACKGROUND Local inflammation associated with solid tumors commonly results from factors released by tumor cells and the tumor stroma, and promotes tumor progression. Cancer associated fibroblasts comprise a majority of the cells found in tumor stroma and are appealing targets for cancer therapy. Here, our aim was to determine the efficacy of targeting(More)
SUMMARY The hypoxia inducible transcription factors (HIFs) control many mediators of vascular response, including both angiogenic factors and small molecules such as nitric oxide (NO). In studying how endothelial HIF response itself affects metastasis, we found that loss of HIF-1a in endothelial cells reduces NO synthesis, retards tumor cell migration(More)
phage gene expression. Although the mechanisms by which oxidized LDL (oxLDL) regulates cellular gene expression are still poorly understood, recent work suggests that transcriptional pathways involving nuclear receptors mediate many biological effects of oxidized by providing the cell with oxidized fatty acid ligands of University of Debrecen the receptor(More)
A growing body of evidence indicates that interactions between neoplastic cells and tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) are crucial in promoting tumor cell invasion and progression. Macrophages have an ambiguous role in these processes as this M1 phenotype correlates with tumoricidal capacity, whereas TAMs of M2 phenotype(More)
The hypoxia inducible transcription factors (HIFs) control many mediators of vascular response, including both angiogenic factors and small molecules such as nitric oxide (NO). In studying how endothelial HIF response itself affects metastasis, we found that loss of HIF-1α in endothelial cells reduces NO synthesis, retards tumor cell migration through(More)
The tumor microenvironment (TME) mediates immunosuppression resulting in tumor cell escape from immune surveillance and cancer vaccine failure. Immunosuppression is mediated by the STAT-3 transcription factor, which potentiates signaling in tumor and immune cells. Because immunosuppression continues to be a major inhibitor of cancer vaccine efficacy, we(More)
1 Targeted therapeutic remodeling of the tumor microenvironment improves a HER-2 DNA vaccine and prevents recurrence in a murine breast cancer model. Running Title: Leg-NP-CDDO and a HER-2 vaccine prevent cancer recurrence. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author manuscripts have been peer(More)
  • 1