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UNLABELLED Nicotinic acetylcholine receptors (nAChRs) have been implicated in a variety of central processes, such as learning and memory and analgesia. These receptors also mediate the reinforcing properties of nicotine in tobacco products and are increased in postmortem samples of brains of smokers. On the other hand, brains of individuals who have died(More)
Major neurochemical effects of methamphetamine include release of dopamine (DA), serotonin (5-HT), and norepinephrine (NE) via a carrier-mediated exchange mechanism. Preclinical research supports the hypothesis that elevations of mesolimbic DA mediate the addictive and reinforcing effects of methamphetamine and amphetamine. This hypothesis has not been(More)
systemic inflammation, as expressed by increased IgG and resulting from colonisation with pathogens and irrespective of blood pressure or diabetes status. Conversely, in adult CF patients, CFRD seems to influence arterial stiffness [4]. This discrepancy between adults and children may indicate that the changes in the arterial wall architecture appear only(More)
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