Dean Laurence Harris

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PURPOSE To determine the safety and feasibility of combining intratumoral reovirus and radiotherapy in patients with advanced cancer and to assess viral biodistribution, reoviral replication in tumors, and antiviral immune responses. EXPERIMENTAL DESIGN Patients with measurable disease amenable to palliative radiotherapy were enrolled. In the first stage,(More)
BACKGROUND There are no data regarding the long-term outcomes of prolene hernia system (PHS) mesh in the published reports. The aim of the study was to compare the short-term and long-term outcomes of the PHS mesh with the Lichtenstein mesh technique. METHODS Sixty-four patients with inguinal hernia were randomized to undergo either a PHS or a(More)
BACKGROUND Bone metastases from renal cell carcinoma (RCC) are a major cause of morbidity. Post hoc analysis has suggested that bone turnover markers can identify patients at risk of skeletal-related events (SREs) among those receiving zoledronic acid. This study sought to evaluate the effect on bone metastases of everolimus alone compared with everolimus(More)
Early clinical trials of reovirus administered via the intratumoral or intravenous routes in patients with advanced cancers established the safety profile and MTD of these agents. Reovirus is an orphan virus and is the cause of a well-documented subclinical syndrome. Preclinical evidence of the novel mechanisms of anticancer activity of reovirus provided(More)
402 Background: Bone metastases (BM) from renal cell carcinoma (RCC) are common, cause morbidity, and have been identified as an adverse prognostic feature. Previous trials have not assessed the effects of modern therapies on BM from RCC. Randomized data has demonstrated that zoledronic acid (Z) reduces skeletal-related-events (SREs) in RCC patients (pts).(More)
PITZER STATED tha t every ef for t would be made to establish a scholarship program "not jus t for a small portior of the admitted students but fo r everyone." The university has " tentat ively" decided to make use of the College Scholarship Service (used by most universities) for preliminary screening of financial aid applicants. When asked by the Thresher(More)
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