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Effects of peripheral CCK receptor blockade on feeding responses to duodenal nutrient infusions in rats.
Type A cholecystokinin receptor (CCKAR) antagonists differing in blood-brain barrier permeability were used to test the hypothesis that duodenal delivery of protein, carbohydrate, and fat producesExpand
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Relaxin decreases the severity of established hepatic fibrosis in mice
Hepatic fibrosis is characterized by excess collagen deposition, decreased extracellular matrix degradation and activation of the hepatic stellate cells. The hormone relaxin has shown promise in theExpand
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Monocyte activation by an oral immunomodulator (bestatin) in lymphoma patients following autologous bone marrow transplantation
Abstract Bestatin (ubenimex), an inhibitor of aminopeptidase, is an oral immunomodulator that binds to CD13 (aminopeptidase N) on macrophages/monocytes. To examine its immunomodulatory effect afterExpand
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Effects of amylin-related peptides on food intake, meal patterns, and gastric emptying in rats.
We previously demonstrated that amylin inhibits food intake and gastric emptying in rats with half-maximal effective doses (ED(50)s) of 8 and 3 pmol x kg(-1) x min(-1) and maximal inhibitions of 78Expand
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Degradation of Relaxin Family Peptides by Insulin‐Degrading Enzyme
Insulin‐degrading enzyme (IDE) is a ubiquitously expressed metalloproteinase responsible for the intracellular degradation of insulin. IDE also interacts with other members of the insulinExpand
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Expression of green fluorescent protein in human foreskin fibroblasts for use in 2D and 3D culture models
The availability of fibroblasts that express green fluorescent protein (GFP) would be of interest for the monitoring of cell growth, migration, contraction, and other processes within theExpand
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Relaxin Reduces Fibrosis in Models of Progressive and Established Hepatic Fibrosis
The effect of relaxin administration before (prevention) or after (treatment) the establishment of hepatic fibrosis in a mouse model was examined. In the prevention study, relaxin reduced collagenExpand
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Effects of peripheral CCK receptor blockade on gastric emptying in rats.
Type A CCK receptor (CCKAR) antagonists differing in blood-brain barrier permeability [devazepide penetrates; the dicyclohexylammonium salt of Nalpha-3-quinolinoyl-d-Glu-N,N-dipentylamide (A-70104)Expand
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