Diane M. Simeone2
Daniel Normolle2
2Diane M. Simeone
2Daniel Normolle
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BACKGROUND Curcumin is the major yellow pigment extracted from turmeric, a commonly-used spice in India and Southeast Asia that has broad anticarcinogenic and cancer chemopreventive potential. However, few systematic studies of curcumin's pharmacology and toxicology in humans have been performed. METHODS A dose escalation study was conducted to determine(More)
  • Vitor M Faca, Kenneth S Song, Hong Wang, Qing Zhang, Alexei L Krasnoselsky, Lisa F Newcomb +22 others
  • 2008
BACKGROUND The complexity and heterogeneity of the human plasma proteome have presented significant challenges in the identification of protein changes associated with tumor development. Refined genetically engineered mouse (GEM) models of human cancer have been shown to faithfully recapitulate the molecular, biological, and clinical features of human(More)
BACKGROUND Cancer serum protein profiling by mass spectrometry has uncovered mass profiles that are potentially diagnostic for several common types of cancer. However, direct mass spectrometric profiling has a limited dynamic range and difficulties in providing the identification of the distinctive proteins. We hypothesized that distinctive profiles may(More)
There have been an increasing number of large research consortia in recent years funded by the National Cancer Institute (NCI) to facilitate multi-disciplinary, multi-institutional cancer research. Some of these consortia have central data collection plans similar to a multi-center clinical trial whereas others plan to store data locally and pool or share(More)
  • Tingting Yue, Kevin A. Maupin, Brian Fallon, Lin Li, Katie Partyka, Michelle A. Anderson +8 others
  • 2011
The CA 19-9 assay detects a carbohydrate antigen on multiple protein carriers, some of which may be preferential carriers of the antigen in cancer. We tested the hypothesis that the measurement of the CA 19-9 antigen on individual proteins could improve performance over the standard CA 19-9 assay. We used antibody arrays to measure the levels of the CA 19-9(More)
  • Su-Hyung Hong, David E. Misek, Hong Wang, Eric Puravs, Robert Hinderer, Thomas J. Giordano +5 others
  • 2006
Pancreatic cancer has a poor prognosis, in part due to lack of early detection. The identifi cation of circulating tumor antigens or their related autoantibodies provides a means for early cancer diagnosis. We have used a proteomic approach to identify proteins that commonly induce a humoral response in pancreatic cancer. Proteins from a pancreatic(More)
  • Suzanna M. Zick, Mack T. Ruffin, Zora Djuric, Daniel Normolle, Dean E. Brenner
  • 2010
AbstrAct Zingiber officinale is one of the most commonly used spices. We developed a method to determine the main pungent ginger constituents, 6-, 8-and 10-gingerols and 6-shogaol in human plasma. Quantitation was achieved using a reversed-phase c 18 column using high-performance liquid chromatography with elec-trochemical detection. The assay was linear(More)
BACKGROUND Recent reports suggest increase in estrogen receptor (ER), progesterone receptor (PR) negative breast cancer yet little is known about histology or receptor status of breast cancer in Indian/Pakistani women.in the U.S. METHODS We examined the United States National Cancer Institute's Surveillance Epidemiology and End Results (SEER) Cancer(More)
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