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A method for estimating structural properties of random media is described. The size, number density, and scattering strength of particles are estimated from an analysis of the radio frequency (rf) echo signal power spectrum. Simple correlation functions and the accurate scattering theory of Faran [J.J. Faran, J. Acoust. Soc. Am. 23, 405-418 (1951)], which(More)
Metabotropic glutamate receptors (mGluRs), which are coupled to second messenger pathways via G proteins, modulate glutamatergic and GABAergic neurotransmission. Because of their role in modulating neurotransmission, mGluRs are attractive therapeutic targets for anxiety disorders. Previously we showed that mGluR8(-/-) male mice showed higher measures of(More)
NMDA receptors are known to be involved in nociceptive transmission and pain processing. Many structurally diverse NMDA antagonists have been reported to have activity in both animal models and clinical models of neuropathic pain. Untoward side effects such as ataxia and sedation have severely limited the clinical uses of this class of potential(More)
Herein we describe the discovery of compounds that are competitive antagonists of the CP101-606 binding site within the NR2B subtype of the NMDA receptor. The compounds identified do not possess phenolic functional groups such as those in ifenprodil and related analogs. Initial identification of hits in this series focused on a basic, secondary amine side(More)
We present a statistical analysis of the maximum intensity projection (MIP) algorithm, which is commonly used for MR angiography (MRA). The analysis explains why MIP projection images display as much as a twofold increase in signal- and contrast-to-noise ratios over those of the source image set. This behavior is demonstrated with simulations and in phantom(More)
Although optimal decision functions for many simple detection/discrimination tasks can be cast in a form linear in the signal data, more complicated tasks require the addition of higher-order terms. This is typically the case when parameter uncertainty is allowed, in imaging for example, for the detection of a target of known size and shape but unknown(More)
PLEURAL MESOTHEILOMAS are known to be associated with exposure to asbestos in man (Wagner et al. 1960). Intrapleural injection of asbestos has been shown to produce mesotheliomas in rats (Wagner & Berry, 1969). By exploiting this model we have shown that these tumours may be transplanted s.c. into syngeneic rats (Brown et al., 1980). Seven such tumours have(More)
EXPERIMENTAL and pathological investigations have shown asbestos to be associated with mesothelioma in animals and man (Wagner & Berry, 1969; Wagner et al., 1960). In man the development of this neoplasm can take as long as 30-40 years after the first exposure to asbestos (Selikoff & Lee, 1978) and a comparable long latency period (18 months to 2 years) is(More)
Given several images of the same slice, a linear filter can produce an image in which the contrast-to-noise ratio (CNR) between pathological and normal tissues is greater than in any of the initial images. To distinguish the pathology from more than one tissue, the filter should optimize the set of CNRs between the pathology and each of the interfering(More)
Reference cultures derived from a transplantable rat mesothelioma were obtained by cloning cells three times in soft agar. Each line, designated "CARM-Lines", was selected on the basis of their epithelial or fibroblastic phenotype, and their uniform morphology. Three epithelial lines were used for more detailed in vitro studies comparing morphological and(More)