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Conventional model-based or statistical analysis methods for functional MRI (fMRI) are easy to implement, and are effective in analyzing data with simple paradigms. However, they are not applicable in situations in which patterns of neural response are complicated and when fMRI response is unknown. In this paper the "neural gas" network is adapted and… (More)
A woman with severe anorexia following a brain injury, who had been fitted with a gastrostomy, was admitted to the Regional Brain Injury Unit for rehabilitation. Two years after the injury, all her dietary intake is oral but she will not yet ingest solids. The causes of this condition and its management are described and the literature is reviewed.
Following a road-traffic accident, an 18-year-old man developed episodic dyscontrol which brought him into conflict with the law. Two years after the accident, treatment with carbamazepine was initiated and further aggressive outbursts subsided. The efficacy and mode of action of carbamazepine is discussed and the literature reviewed.
Conventional model—based or statistical analysis methods for functional MItT (fMRI) are easy to implement, and are effective in analyzing data with simple paradigms. However, they are not applicable in situations in which patterns of neural response are complicated and when fMRI response is unknown. In this paper the "neural gas" network is adapted and… (More)
OBJECTIVE To determine whether women with the urethral syndrome can be distinguished from those with urinary tract infection by case notes, clinical symptoms, or psychiatric state. DESIGN Longitudinal survey of consecutive women presenting with dysuria and frequency. SETTING General practice and community. SUBJECTS 58 patients with the urethral… (More)
T he most exciting science in the 21st century is likely to evolve among, not within, traditional disciplines. Physical scientists, mathematicians, and engineers, concerned with understanding and designing complex systems, can offer invaluable viewpoints and approaches to biologists. Conversely, biological systems provide new challenges for mathematics and… (More)
This paper presents new model—free fMRI methods based on independent component analysis. Commonly used methods in analyzing fMRI data, such as the Student's t-test and cross correlation analysis, are model-based approaches. Although these methods are easy to implement and are effective in analyzing data with simple paradigms, they are not applicable in… (More)