De-xin Yuan

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Sensitivity to excitotoxic damage was assessed in young adult, mature and aged male Sprague-Dawley rats. Kainic acid was injected into the hippocampus and the size of the hippocampal lesion rated. Intrahippocampal injection of kainic acid produced lesions in aged animals that were significantly smaller than lesions in the young rats (P < 0.05), while lesion(More)
BACKGROUND Radiation-induced bystander effect (RIBE) has important implication in tumour radiotherapy, but the bystander signals are still not well known. METHODS The role of cytochrome-c (cyt-c) and free radicals in RIBE on human hepatoma cells HepG2 was investigated by detecting the formation of bystander micronuclei (MN) and the generation of(More)
OBJECTIVE To investigate the effects of brain-derived neurotrophic factor (BDNF) on survival, migration and differentiation of neural stem cells (NSCs) transplanted into the brain of newborn rats with hypoxic-ischemic brain damage and the recovery of nervous functions. METHODS The NSCs were separated from hippocampus of neonatal Wistar rats within 24 h(More)
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