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OBJECTIVE To investigate the effects of brain-derived neurotrophic factor (BDNF) on survival, migration and differentiation of neural stem cells (NSCs) transplanted into the brain of newborn rats with hypoxic-ischemic brain damage and the recovery of nervous functions. METHODS The NSCs were separated from hippocampus of neonatal Wistar rats within 24 h(More)
OBJECTIVE To evaluate the efficacy of combined transplantation of neurotrophin-3 and neural stem cells in treatment of hypoxic-ischemic brain injury in rats, and study the possible mechanism. METHODS Neural stem cells (NSCs) isolated from hippocampi of newborn wistar rats were cultured and identified. The hypoxic-ischemic brain injury models established(More)
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