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  • Lihui Luo, De-Quan Li, Amish Doshi, William J. Farley, Rosa María Corrales, Stephen C. Pflugfelder
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • 2004 (First Publication: 1 December 2004)
  • PURPOSE To evaluate whether experimentally induced dry eye in mice activates mitogen-activated protein kinase (MAPK) signaling pathways, c-Jun N-terminal kinases (JNK), extracellular-regulatedContinue Reading
  • Scheffer C. G. Tseng, De-Quan Li, Xin Hua Ma
  • Medicine, Biology
  • Journal of cellular physiology
  • 1999 (First Publication: 1 June 1999)
  • Down-regulation of the transforming growth factor-beta (TGF-beta) signaling system is a strategy for preventing scarring during wound healing. Human corneal and limbal fibroblasts were cultured onContinue Reading
    Hyperosmolarity has been recognized to be a pro-inflammatory stress to the corneal epithelium. The cell signalling pathways linking hyperosmolar stress and inflammation have not been well elucidated.Continue Reading
  • De-Quan Li, Zhuo Chen, Xiu Jun Song, Lihui Luo, Stephen C. Pflugfelder
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • 2004 (First Publication: 1 December 2004)
  • PURPOSE To investigate whether exposure of human corneal epithelial cells to hyperosmotic stress activates the c-Jun NH(2)-terminal kinase (JNK) stress-activated protein kinase (SAPK) pathway, andContinue Reading
  • Cintia S de Paiva, Rosa María Corrales, +4 authors Stephen C. Pflugfelder
  • Biology, Medicine
  • Experimental eye research
  • 2006 (First Publication: 1 September 2006)
  • We investigated the effects of corticosteroid and doxycycline on expression of matrix metalloproteinase (MMP)-9 and inflammatory cytokines and activation of mitogen-activated protein kinase (MAPK)Continue Reading