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Learning effective feature representations and similarity measures are crucial to the retrieval performance of a content-based image retrieval (CBIR) system. Despite extensive research efforts for decades, it remains one of the most challenging open problems that considerably hinders the successes of real-world CBIR systems. The key challenge has been(More)
The International Symposium on Biomedical Imaging (ISBI) held a grand challenge to evaluate computational systems for the automated detection of metastatic breast cancer in whole slide images of sentinel lymph node biopsies. Our team won both competitions in the grand challenge, obtaining an area under the receiver operating curve (AUC) of 0.925 for the(More)
In this paper, we investigate a search-based face annotation framework by mining weakly labeled facial images that are freely available on the internet. A key component of such a search-based annotation paradigm is to build a database of facial images with accurate labels. This is however challenging since facial images on the WWW are often noisy and(More)
Recent years have witnessed extensive studies on distance metric learning (DML) for improving similarity search in multimedia information retrieval tasks. Despite their successes, most existing DML methods suffer from two critical limitations: (i) they typically attempt to learn a linear distance function on the input feature space, in which the assumption(More)
CONCLUSION This genetic epidemiological study demonstrated that 26.65% of the prelingual deafness in Northern Chinese patients can be detected at younger ages by genetic testing of three common hearing loss genes (GJB2, SLC26A4 and mtDNA A1555G), and thus, early intervention measures could be undertaken to help them in language acquisition. OBJECTIVES The(More)
Cobalt is widespread in the environment and excess dietary Co exposure can result in toxic effects in many organisms. However, whether the multi-biological toxicities caused by Co exposure can be transferred from parents to progeny has not been clarified. In the present study, we analyzed the multiple toxicities of Co to the nematode Caenorhabditis elegans(More)
Nematode Caenorhabditis elegans has been developed in a variety of environmental studies to address adverse effects of a wide range of toxicants. In the present study, we compared the toxicities of three metal oxide nanoparticles (NPs) including TiO(2)-NPs, ZnO-NPs, and SiO(2)-NPs with the same nanosize (30 nm) after prolonged exposure from L1-larvae to(More)
BACKGROUND The first step in infection by Candida albicans is adhesion to host cells or implanted medical devices and this followed by hyphal growth and biofilm formation. Yeast-to-hyphal transition has long been identified as a key factor in fungal virulence. Following biofilm formation, C. albicans is usually less sensitive or insensitive to antifungals.(More)
In despite of the essential functions of zinc as trace element for humans, toxic effects will be pronounced while organisms are exposed to high levels of zinc. However, whether the multiple biological toxicities caused by zinc exposure could be transferred to progeny is still largely unknown. In the present study, we explored the model organism,(More)