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MicroRNAs (miRNAs) are a class of 20-24 nt non-coding RNAs that regulate gene expression primarily through post-transcriptional repression or mRNA degradation in a sequence-specific manner. The roles of miRNAs are just beginning to be understood, but the study of miRNA function has been limited by poor understanding of the general principles of gene(More)
Gut microbes play important roles in regulating fat storage and metabolism. Rhizoma coptidis (RC) and its main active compound, berberine, have either antimicrobial or anti-obesity activities. In the present study, we hypothesize that RC exerts anti-obesity effects that are likely mediated by mechanisms of regulating gut microbes and berberine may be a key(More)
Many new Java runtime optimizations report relatively small, single-digit performance improvements. On modern virtual and actual hardware, however, the performance impact of an optimization can be influenced by a variety of factors in the underlying systems. Using a case study of a new garbage collection optimization in two different Java virtual machines,(More)
Zika virus (ZIKV) is a mosquito-borne flavivirus that usually causes asymptomatic infections or mild illness in humans. However, the unprecedented epidemics of ZIKV in Latin America since early 2015 have made this flavivirus an international health risk (Liu and Zhang, 2016). In particular, the potential association of ZIKV infection with the remarkable(More)
We describe the effect of a particular form of " noise " in benchmarking. We investigate the source of anomalous measurement data in a series of optimization strategies that attempt to improve runtime performance in the garbage collector of a Java virtual machine. The results of our experiments can be explained in terms of the difference in code layout, and(More)
The efficient delivery of therapeutic genes into cells of interest is a critical challenge to broad application of non-viral vector systems. In this research, a novel TPGS-b-(PCL-ran-PGA) nanoparticle modified with polyethyleneimine was applied to be a vector of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and endostatin for cervical(More)
OBJECTIVES Circulating microRNAs (miRNAs) play critical roles in pathogen-host interactions. Aberrant miRNA expression profiles might have specific characteristics for virus strains, and could serve as noninvasive biomarkers for screening and diagnosing infectious diseases. In this study, we aimed to find new potential miRNA biomarkers of hepatitis C virus(More)
Zika virus (ZIKV) used to be an unknown mosquito borne flavivirus, and maintained its limited sylvatic circulation in a few African and Asian countries (Enfissi et al., 2016). Based on available clinical data, the symptoms in human infections with ZIKV are supposed to be similar to other arbovirus infections such as dengue, and characterized by fever, skin(More)