Dayanand Bhardwaj

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A synthetic chimeric peptide of Met-enkephalin and FMRFamide (YGGFMKKKFMRFa), based on MERF was synthesized. This peptide was tested for possible antinociceptive effects using the tail flick test in mice. The effect of the chimeric peptide on morphine antinociception and development of tolerance to the antinociceptive action of morphine was also(More)
One of the efficient mode of treatments of chronic hypertension and cardiovascular disorders has been to restrain the formation of angiotensin-II by inhibiting the action of angiotensin-converting enzyme (ACE) on angiotensin-I. A number of ACE inhibitors (ACEIs) have been put to therapeutic use during the last two decades. The efforts continue towards(More)
A cytogenetic survey was conducted on personnel exposed to petroleum exhaust fumes (vapour and smoke at automobile workshops). The incidence of chromosomal aberrations (CAs) in this population was evaluated. A total of 1.15 +/- 0.22 aberrations were encountered in the exposed group as compared with 0.47 +/- 0.12 aberrations in the age matched controls. The(More)
Cytogenetic investigations were carried out on 50 workers exposed to stone dust in a stone crusher industry and on 25 control subjects never exposed to such dust. The frequency of chromosomal aberrations and sister chromatid exchanges in exposed individuals was significantly higher than that in controls (P less than 0.01). The cytogenetic indices(More)
The oculomotor nerve (ON) provides motor innervation to the eyeball and exhibits alterations in various physiological and pathological conditions, which may result in abnormal ocular movement. Although the nerve has been studied in detail, very few data are available regarding its morphology and changes with aging. Hence, in the present investigation, the(More)
An enzymatically stable analog of YGGFMKKKFMRFamide (YFa), a chimeric peptide of metenkephalin and FMRFa, was synthesised. The antinociceptive effects of intracerebroventricular injections of this analog-[D-Ala2)]YAGFMKKKFMRFamide ([D-Ala2]YFa)-was then investigated using the mouse radiant-heat tail-flick test. [D-Ala2]YFa produced modest to good(More)
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