Day-Uei Li

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Image sensors capable of resolving the time-of-arrival (ToA) of individual pho-tons with high resolution are needed in several applications, such as fluores-cence lifetime imaging microscopy (FLIM), Förster resonance energy transfer (FRET), optical rangefinding, and positron emission tomography. In FRET, for example, typical fluorescence lifetime is of the(More)
A compact real-time fluorescence lifetime imaging microscopy (FLIM) system based on an array of low dark count 0.13µm CMOS single-photon avalanche diodes (SPADs) is demonstrated. Fast background-insensitive fluorescence lifetime determination is achieved by use of a recently proposed algorithm called 'Integration for Extraction Method' Here, IEM is modified(More)
Fluorescence lifetime of dye molecules is a sensitive reporter on local microenvironment which is generally independent of fluorophores concentration and can be used as a means of discrimination between molecules with spectrally overlapping emission. It is therefore a potentially powerful multiplexed detection modality in biosensing but requires extremely(More)
Estimation of signal parameters via rotational invariance techniques is a classical algorithm widely used in array signal processing for direction-of-arrival estimation of emitters. Inspired by this method, a new signal model and new fluorescence lifetime estimation via rotational invariance techniques (FLERIT) were developed for multiexponential(More)