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Inclusions composed of α-synuclein (α-syn), i.e., Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Here, we demonstrate that preformed fibrils generated from full-length and truncated recombinant α-syn enter primary neurons, probably by adsorptive-mediated(More)
Robot assisted medical reachback (RAMR) involves remote medical personnel conducting operator-and robot-mediated victim assessment in an urban search and rescue environment. A simulated medical reachback exercise was developed to examine RAMR. Key findings suggest it is critical for providers and operators to maintain a shared visual space for developing(More)
Many neurodegenerative diseases are characterized by the accumulation of insoluble protein aggregates, including neurofibrillary tangles comprised of tau in Alzheimer's disease and Lewy bodies composed of α-synuclein in Parkinson's disease. Moreover, different pathological proteins frequently codeposit in disease brains. To test whether aggregated(More)
— This study investigates data collected from operating an Inuktun robot in an Urban Search and Rescue (USAR) confined space training exercise task at Virginia Beach Training Center. Data was collected from coding approximately one hour of video. The video had no sound so all analysis is based on the video feed. Indicators of communication, gestures,(More)
Aggregates of α-synuclein (α-syn) accumulate in neurons in Parkinson's disease and other synucleinopathies. These inclusions predominantly localize to axons even in the early stages of the disease, but their affect on axon function has remained unknown. Previously we established a model in which the addition of preformed α-syn fibrils to primary neurons(More)
Here we compared the proteomes of primary fibroblast cultures derived from morphologically normal colonic mucosa of familial adenomatous polyposis (FAP) patients with those obtained from unaffected controls. The expression signature of about 19% of total fibroblast proteins separates FAP mutation carriers from unaffected controls (P < 0.01). More than 4,000(More)
The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis (ALS) and the majority of frontotemporal lobar degeneration (FTLD-TDP) referred to collectively as TDP-43 proteinopathies. To further elucidate mechanisms of pathological TDP-43 processing and identify TDP-43 epitopes that(More)
Rough set analysis is used as a methodology to identify the relative importance of variables for individuals who interact with various computer and other display and communication systems aboard Airborne Warning and Control Systems (AWACS). A goal of the analysis is to determine optimal information display and interpersonal interaction strategies to(More)