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PURPOSE To investigate (1) the mechanism of blood-retinal barrier breakdown induced by protein kinase C (PKC) activation (2) the relationship between PKC activation and vascular endothelial growth factor (VEGF) in 2-week streptozotocin-induced diabetes. METHODS Retinal PKC activities, retinal and vitreous concentration of VEGF protein were conducted by(More)
The form has become an important abstraction for data management in an office application environment. Structured office forms present data to users in an easily understood and easily manipulated manner. In this paper we classify forms systems in terms of three dimensions: data structuring, user interfaces, and programming interfaces. Current forms systems(More)
PURPOSE Hyperglycemia-induced mitochondrial reactive oxygen species (ROS) production plays an important role in the development of complications of diabetes such as retinopathy. However, whether pigment epithelium-derived factor (PEDF) can decrease ROS production remains uncertain. The aim of this study was to clarify whether PEDF can decrease(More)
In this paper we introduce a high level nonprocedural language Form Operation by Example (FOBE) to manipulate forms in office systems. The form data model is selected as the basis for the user interface. The idea of query-by-example is applied to forms. A precise semantics definition of the language is given. FOBE has a predetermined structure. It combines(More)
BACKGROUND The accumulation of advanced glycated end products (AGEs) in retinal blood vessels is one of the major etiological factors contributing to diabetic retinopathy. Aminoguanidine (AG) is one of the most extensively used inhibitors of AGEs formation. The aim of this study was to investigate whether AG could protect the development of diabetic(More)
PURPOSE In primary open angle glaucoma (POAG) patients, elevated intraocular pressure usually leads to extracellular matrix remodeling and astrocytes activation. Thus, lamina cribrosa (LC) cells may play an important role in POAG progression. The objective of this study was to comprehensively explore gene expression profiles in LC cells of POAG patients. (More)
Abstract Background. Diabetic retinopathy has been shown to be directly associated with the degree and duration of hyperglycemia, and advanced glycosylation end products (AGEs) have been implicated in this pathological process. The purpose of the experiments reported here was to study the effect of AGE deposition on retinal vascular damage which leads to(More)
Diabetic retinopathy (DR) is a common complication of diabetes. DR obstructs blood supply to the retina and has serious and long-lasting detrimental effects on quality of life. Panretinal photocoagulation, a laser surgical intervention, is advocated for early treatment of DR to prevent visual loss; however, results from studies reporting its efficacy vary(More)
The selection of a proper set of operations for a database machine has a great influence on the performance of the overall system. In this paper, we will discuss the data language requirements of database machines. The data language for a proposed relational database machine is presented. Methods for supporting hierarchical and network interfaces using a(More)