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- Jaap W. Mandema, Davide Verotta, Lewis B. Sheiner
- Journal of Pharmacokinetics and Biopharmaceutics
- 1992

One major task in clinical pharmacology is to determine the pharmacokinetic-pharmacodynamic (PK-PD) parameters of a drug in a patient population. NONMEM is a program commonly used to build populationâ€¦ (More)

- Davide Verotta
- Critical reviews in biomedical engineering
- 1996

The response at time t (R(t)) of a (causal linear time invariant) system to an input A(t) is represented by: [equation: see text] where K(t) is called the unit impulse response function of theâ€¦ (More)

- JÃ¼rgen SchÃ¼ttler, Donald. R. Stanski, +4 authors Lewis B. Sheiner
- Journal of Pharmacokinetics and Biopharmaceutics
- 1987

The pharmacodynamics of a racemic mixture of ketamine R,S (Â±)-ketamine and of each enantiomer, S(+)-ketamine and R(âˆ’)-ketamine, were studied in five volunteers. The median frequency of theâ€¦ (More)

- Marta Valle, Enrico di Salle, +4 authors Davide Verotta
- British journal of clinical pharmacology
- 2005

AIMS
Exemestane (Aromasin) is an irreversible aromatase inactivator used for the treatment of postmenopausal women with advanced breast cancer. The objective of this study was to evaluate the effectâ€¦ (More)

- Karin E. Fattinger, Davide Verotta
- Journal of Pharmacokinetics and Biopharmaceutics
- 1995

In a pharmacokinetics context deconvolution facilitates the following: (i) Given data obtained after intravascular (generally intravenous) input one may estimate the disposition function; (ii) givenâ€¦ (More)

- Dongwoo Kang, Davide Verotta
- Journal of Pharmacokinetics and Pharmacodynamics
- 2006

To solve the problem of estimating an unknown input function to a linear time invariant system we propose an adaptive non-parametric method based on reversible jump Markov chain Monte Carlo (RJMCMC).â€¦ (More)

- Chantal Csajka, David Drover, Davide Verotta
- Pharmaceutical Research
- 2005

The aim of this study was to evaluate the utility of a parametric deconvolution method using a sum of inverse Gaussian functions (IG) to characterize the absorption and concentrations vs. timeâ€¦ (More)

- Davide Verotta, Lewis B. Sheiner
- Journal of Pharmacokinetics and Biopharmaceutics
- 1991

We present an approach to the analysis of pharmacodynamic (PD) data arising from non-steadystate experiments, meant to be used when only PD data, not pharmacokinetic (PK) data, are available. Theâ€¦ (More)

- Liusheng Huang, Janus Haagensen, Davide Verotta, Patricia Lizak, Francesca T. Aweeka, Katherine Yang
- Journal of chromatography. B, Analyticalâ€¦
- 2014

To support the development of a dynamic in vitro human pharmacokinetic/pharmacodynamic simulation model for biofilm-mediated infections and study stability of meropenem, an LC-MS/MS method for theâ€¦ (More)

- Davide Verotta, Franziska Schaedeli
- Mathematical biosciences
- 2002

Human immunodeficiency virus (HIV) dynamics represent a complicated variant of the text-book case of non-linear dynamics: predator-prey interaction. The interaction can be described as naturallyâ€¦ (More)