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  • D Perla
  • 1936
1. Removal of the hypophysis in adult rats is followed by progressive atrophy of the spleen. At the end of 2 months the ratio of spleen weight to body weight is one-half the normal. The administration of hypophyseal emulsion repairs to a considerable degree the atrophy of the spleen in such animals. 2. Hypophysectomy completely inhibits the regeneration of(More)
An aqueous lipoid extract of ox spleen was prepared which protects adult male albino rats of carrier stock in a large percentage of instances against Bartonella muris anemia following splenectomy. It is suggested that the extract contains a specific hormonal substance.
The pathological changes that follow a severe infection with Bartonella muris in the adult or young albino rat are: First, those that result from the release of large quantities of cellular debris in the circulating blood. There is phagocytic activity and hyperplasia of the endothelial elements of the liver, thymus, lymph nodes and, in the young rat, of(More)
In Bartonella muris carrier stock certain changes are observed in the lymphoblastic and reticular and endothelial elements after splenectomy and recovery from the anemia. These changes appear 3 to 5 months after splenectomy and are associated with immunity to further infection with Bartonella muris. The changes consist primarily of hyperplasia of hemolymph(More)
The effect on Bartonella muris anemia of adding copper or iron or both to an adequate diet was studied. The addition to the diet of copper (0.1 mg. per rat per day), or iron (1 mg. per day), or both during a period of 2 days prior to splenectomy and 1 month subsequent thereto failed to protect adult albino rats against Bartonella muris anemia. The addition(More)
  • D Perla
1. After intraperitoneal inoculation of guinea pigs with tubercle bacilli, the microorganisms may appear in the feces and elimination may persist during 1 week. Subsequently during several weeks no tubercle bacilli can be recovered from the feces. 2. When tuberculosis is widely disseminated in the body of guinea pigs, tubercle bacilli are discharged with(More)
1. The blood chemistry of normal adult rats and of splenectomized adult rats suffering with Bartonella muris anemia has been studied. 2. Non-protein nitrogen rises with the increase in severity of the anemia. Total serum proteins, serum albumin and serum globulin decrease slightly. Uric acid remains unchanged. 3. Serum chloride concentration remains(More)
Table I and Figs. 1 and 2 summarize the experiments done on 150 rats. Suprarenalectomy in rats is followed by a striking depression in antibody formation most marked during the first week following the operation. Repeated injections of large amounts of isotonic sodium chloride or sodium acetate solutions restore the antibody titer to normal. The effect of(More)