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Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry
BACKGROUND Centrioles are cylindrical microtubule-based structures whose assembly is critical for the formation of cilia, flagella, and centrosomes. The centriole proximal region harbors a cartwheelExpand
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Cooperative kinking at distant sites in mechanically stressed DNA
In cells, DNA is routinely subjected to significant levels of bending and twisting. In some cases, such as under physiological levels of supercoiling, DNA can be so highly strained, that itExpand
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Molecular and dimensional profiling of highly purified extracellular vesicles by fluorescence fluctuation spectroscopy.
Cells secrete extracellular vesicles (EVs) into their microenvironment that act as mediators of intercellular communication under physiological conditions and in this context also activelyExpand
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Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint
Amyloid‐beta (Aβ) peptide oligomerization plays a central role in the pathogenesis of Alzheimer's disease (AD), and Aβ oligomers are collectively considered an appealing therapeutic target for theExpand
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KAP1 is an antiparallel dimer with a natively functional asymmetry
KAP1 (KRAB-domain associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. InExpand
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A Direct Observation of Highly Bent and Twisted DNA at the Single Molecule Level
Many DNA-binding proteins interact with twisted or bent DNA. To characterize the activity of these proteins as a function of the torsional and bending stresses, we must first understand how theseExpand
Optimisation de la cryo microscopie électronique pour les études des minicercles d'ADN
RESUME : Bien que les proprietes physiques de la structure de l'ADN aient ete intensivement etudiees pendant plus de 50 ans il y a encore beaucoup de questions importantes qui attendent des reponses.Expand
Aβ oligomerization is associated with the generation of a typical peptide fragment 1 fingerprint . 2 3
46 47 Amyloid-beta (Aβ) peptide oligomerization plays a central role in the pathogenesis of 48 Alzheimer’s disease (AD) and Aβ oligomers are collectively considered an appealing 49 therapeutic targetExpand
Targeting specific epitopes in neurotoxic beta-amyloid oligomers using a novel class of antibodies
Background:MicroRNAs are implicated in the pathogenesis of Alzheimer’s disease (AD). However, the change of microRNA expression and the impact of dys-regulated microRNAs in AD remains unclear.Expand