Davide Cangelosi

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Neuroblastoma (NB) is an aggressive pediatric tumor, responsible for 15% of cancer-related deaths in childhood, lacking an effective treatment in its advanced stages. The P2X7 receptor for extracellular ATP was associated to NB cell proliferation and recently emerged as a promoter of tumor engraftment, growth and vascularization. In an effort to identify(More)
The simulation of chemical reacting systems is one of the most challenging topics in Systems Biology, due to their complexity and inherent randomness. The Gillespie's Stochastic Simulation Algorithm (SSA) is a standard algorithm to simulate well-stirred biochemical systems, butthe computational burden makes this algorithm slow to compute for many realistic(More)
In this paper, we introduce a new notion of motifs, called masks, that succinctly represent the repeated patterns for an input sequence T of n symbols drawn from an alphabet Σ. We show how to build the set of all maximal masks of length L and quorum q, in O(2Ln) time and space in the worst case. We analytically show that our algorithms perform better than(More)
Neuroblastoma is the most common pediatric solid tumor. About fifty percent of high risk patients die despite treatment making the exploration of new and more effective strategies for improving stratification mandatory. Hypoxia is a condition of low oxygen tension occurring in poorly vascularized areas of the tumor associated with poor prognosis. We had(More)
Cancer patient's outcome is written, in part, in the gene expression profile of the tumor. We previously identified a 62-probe sets signature (NB-hypo) to identify tissue hypoxia in neuroblastoma tumors and showed that NB-hypo stratified neuroblastoma patients in good and poor outcome [1]. It was important to develop a prognostic classifier to cluster(More)
More than fifty percent of neuroblastoma (NB) patients with adverse prognosis do not benefit from treatment making the identification of new potential targets mandatory. Hypoxia is a condition of low oxygen tension, occurring in poorly vascularized tissues, which activates specific genes and contributes to the acquisition of the tumor aggressive phenotype.(More)
Davide Cangelosi1, Fabiola Blengio, Rogier Versteeg2, Angelika Eggert3, Alberto Garaventa4, Claudio Gambini5, Massimo Conte4, Alessandra Eva1, Luigi Varesio1 1Laboratory of Molecular Biology, Gaslini Institute, Genoa, Italy 2Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands 3Department of Pediatric(More)
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