David da Mata Lopes

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Dear Editor, A 49-year-old woman presented with stage IA diffuse large B cell lymphoma (DLBCL) of the uterine cervix. She received four courses of R-CHOP (rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone) and two cycles of RICE (rituximab, ifosfamide, carboplatin, and etoposide), followed by local tomotherapy. A complete remission was(More)
BACKGROUND Ipsilateral recurrence after nephron-sparing surgery (NSS) is rare, and little is known about its specific determinants. OBJECTIVE To determine clinical or pathologic features associated with ipsilateral recurrence after NSS performed for renal cell carcinoma (RCC). DESIGN, SETTING, AND PARTICIPANTS We analysed 809 NSS procedures performed at(More)
Thioredoxins are multifunctional oxidoreductase proteins implicated in the antioxidant cellular apparatus and oxidative stress. They are involved in several pathologies and are promising anticancer targets. Identification of noncatalytic binding sites is of great interest for designing new allosteric inhibitors of thioredoxin. In a recent work, we predicted(More)
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