Learn More
Ubiquitination is a post-translational modification in which one or more 76 amino acid polypeptide ubiquitin molecules are covalently linked to the lysine residues of target proteins. Ubiquitination is the main pathway for protein degradation that governs a variety of eukaryotic cellular processes, including the cell-cycle, vesicle trafficking, antigen(More)
An s-graph is a graph with two kinds of edges: subdivisible edges and real edges. A realisation of an s-graph B is any graph obtained by subdividing subdivisible edges of B into paths of arbitrary length (at least one). Given an s-graph B, we study the decision problem Π B whose instance is a graph G and question is " Does G contain a realisation of B as an(More)
Nerve injury, a significant cause of disability, may be treated more effectively using nerve guidance channels containing longitudinally aligned fibers. Aligned, electrospun nanofibers direct the neurite growth of immortalized neural stem cells, demonstrating potential for directing regenerating neurites. However, no study of neurite guidance on these(More)
The role of iron deficiency in noise-induced hearing loss (NIHL) was evaluated in 64 rats of four different experimental groups. Iron-deficient rats (ID-rats) and normal rats (N-rats) were simultaneously exposed to a steady state white noise (20-10,000 Hz) at 110 dB SPL for 30 min. Unexposed ID- and N-rats served as controls. In N-rats the temporary(More)
Many microbial pathogens deliver effector proteins via the type III secretion system into infected host cells. Elucidating the function of these effectors is essential for our understanding of pathogenesis. Here, we describe biochemical and structural characterization of an effector protein (NleL) from Escherichia coli O157:H7, a widespread pathogen causing(More)
Bacteria secrete peptides and proteins to communicate, to poison competitors, and to manipulate host cells. Among the various protein-translocation machineries, the peptidase-containing ATP-binding cassette transporters (PCATs) are appealingly simple. Each PCAT contains two peptidase domains that cleave the secretion signal from the substrate, two(More)
Human pressure on ecosystems is among the major drivers of biodiversity loss. As biodiversity plays a key role in supporting the human enterprise, its decline puts the well-being of human societies at risk. Halting biodiversity loss is therefore a key policy priority, as reflected in the 2020 Aichi Biodiversity Targets under strategic goal A. The Ecological(More)
An s-graph is a graph with two kinds of edges: subdivisible edges and real edges. A realisation of an s-graph B is any graph obtained by subdividing subdivisible edges of B into paths of arbitrary length (at least one). Given an s-graph B, we study the decision problem Π B whose instance is a graph G and question is ''Does G contain a realisation of B as an(More)
An s-graph is a graph with two kind of edges: subdivisible edges and real edges. A realisation of an s-graph B is any graph obtained by subdividing subdivisible edges of B into paths of length at least one. Given an s-graph B, we study the decision problem Π B. Its instance is any graph G, its question is " Does G contains a realisation of B as an induced(More)
  • 1