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The subthalamic nucleus (STN) and external globus pallidus (GP) form a recurrent excitatory-inhibitory interaction within the basal ganglia. Through a computational model of these interactions we show that, under the influence of appropriate external input, the two nuclei can be switched between states of high and low activity or can generate oscillations(More)
The requirements for neuroinformatics to make a significant impact on neuroscience are not simply technical--the hardware, software, and protocols for collaborative research--they also include the legal and policy frameworks within which projects operate. This is not least because the creation of large collaborative scientific databases amplifies the(More)
There is significant interest amongst neuroscientists in sharing neuroscience data and analytical tools. The exchange of neuroscience data and tools between groups affords the opportunity to differently re-analyze previously collected data, encourage new neuroscience interpretations and foster otherwise uninitiated collaborations, and provide a framework(More)
The subthalamic nucleus (STN) is the primary target for the chronic deep brain stimulation treatment of Parkinson's disease. STN neurons exhibit a variety of characteristic properties that may play a key role in the overall population response to deep brain stimulation. Neuroinformatics techniques, in particular computational modeling, provide a method of(More)
SpiNet is a novel simulation environment for building and analyzing large networks of spiking neurons. Heterogeneous networks with complex architectures can be easily built and simulated without detailed knowledge of a particular programming language or script language interpreter. SpiNet is composed of two components: a simulation engine, written in C(More)
Neuroinformatics: the integration of shared databases and tools towards integrative neuroscience. ABSTRACT There is significant interest amongst neuroscientists in sharing neuroscience data and analytical tools. The exchange of neuroscience data and tools between groups affords the opportunity to differently re-analyze previously collected data, encourage(More)
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