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AIM To estimate the prevalence of Alzheimer's disease (AD) and other dementias in the USA using a nationally representative sample. METHODS The Aging, Demographics, and Memory Study sample was composed of 856 individuals aged 71 years and older from the nationally representative Health and Retirement Study (HRS) who were evaluated for dementia using a(More)
We report the complete sequence of an extreme halophile, Halobacterium sp. NRC-1, harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 families and organized into a large chromosome and 2 related minichromosomes. The Halobacterium NRC-1 genome codes for 2,630 predicted proteins, 36% of which are unrelated to any(More)
OBJECTIVE Estimates of incident dementia, and cognitive impairment, not dementia (CIND) (or the related mild cognitive impairment) are important for public health and clinical care policy. In this paper, we report US national incidence rates for dementia and CIND. METHODS Participants in the Aging, Demographic, and Memory Study (ADAMS) were evaluated for(More)
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723(More)
This thesis combines an epistemological concern about induction with a computational exploration of inductive mechanisms. It aims to investigate how inductive performance could be improved by using induction to select appropriate generalisation procedures. The thesis revolves around a meta-learning system, called The Entrencher, designed to investigate how(More)
CONTEXT It is unclear if advance directives (living wills) are associated with end-of-life expenditures and treatments. OBJECTIVE To examine regional variation in the associations between treatment-limiting advance directive use, end-of-life Medicare expenditures, and use of palliative and intensive treatments. DESIGN, SETTING, AND PATIENTS(More)
OBJECTIVE We describe the design and methods of the Aging, Demographics, and Memory Study (ADAMS), a new national study that will provide data on the antecedents, prevalence, outcomes, and costs of dementia and "cognitive impairment, not demented" (CIND) using a unique study design based on the nationally representative Health and Retirement Study (HRS). We(More)
OBJECTIVES To estimate the impact of Medicare Part D on prescription drug coverage among elderly Medicare beneficiaries and to analyze the predictors of program enrollment ("take-up") among those with no prior drug coverage. METHODS Multivariate analyses of data from the 2002, 2004, and 2006 waves of the Health and Retirement Study. RESULTS Take-up of(More)
BACKGROUND Cognitive impairment without dementia is associated with increased risk for disability, increased health care costs, and progression to dementia. There are no population-based prevalence estimates of this condition in the United States. OBJECTIVE To estimate the prevalence of cognitive impairment without dementia in the United States and(More)
BACKGROUND Mechanisms for racial/ethnic disparities in glycemic control are poorly understood. METHODS A nationally representative sample of 1901 respondents 55 years or older with diabetes mellitus completed a mailed survey in 2003; 1233 respondents completed valid at-home hemoglobin A(1c) (HbA(1c)) kits. We constructed multivariate regression models(More)