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In POINT X, a study designed to reflect clinical practice and patient treatment choices, 254 European patients received open-label collagenase for Dupuytren's contracture. The most severely affected joint was treated first in 74% of patients. In total, 52%, 41%, 7%, and 1% of patients selected the little, ring, middle, and index finger, respectively; 79%(More)
Objectives We aimed to examine the characteristics of deep venous flow in the leg in a cast and the effects of a wearable neuromuscular stimulator (geko; FirstKind Ltd) and also to explore the participants' tolerance of the stimulator. Methods This is an open-label physiological study on ten healthy volunteers. Duplex ultrasonography of the superficial(More)
OBJECTIVE This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH). METHODS This review is based on a literature review and practical experience. RESULTS This review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects(More)
Joint replacement in orthopaedic surgery has developed im-measurably over the past four decades, enhancing the lives of millions each year across the world. Well established hip and knee replacements offer 20-year survivorship or more with few post-operative complications. Nevertheless, there are examples of joint implanta-tion causing unexpected harm. Some(More)
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