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As memory accesses become slower with respect to the processor and consume more power with increasing memory size, the focus of memory performance and power consumption has become increasingly important. With the trend to develop multi-threaded, multi-core processors, the demands on the memory system will continue to scale. However, determining the optimal(More)
In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading(More)
The detection of viral pathogens is of critical importance in biology, medicine, and agriculture. Unfortunately, existing techniques to screen for a broad spectrum of viruses suffer from severe limitations. To facilitate the comprehensive and unbiased analysis of viral prevalence in a given biological setting, we have developed a genomic strategy for highly(More)
An elastomeric stamp, containing defined features on the micrometer scale, was used to imprint gold surfaces with specific patterns of self-assembled monolayers of alkanethiols and, thereby, to create islands of defined shape and size that support extracellular matrix protein adsorption and cell attachment. Through this technique, it was possible to place(More)
Performance gains in memory have traditionally been obtained by increasing memory bus widths and speeds. The diminishing returns of such techniques have led to the proposal of an alternate architecture, the fully-buffered DIMM. This new standard replaces the conventional memory bus with a narrow, high-speed interface between the memory controller and the(More)
An ideal model system to study antiviral immunity and host-pathogen co-evolution would combine a genetically tractable small animal with a virus capable of naturally infecting the host organism. The use of C. elegans as a model to define host-viral interactions has been limited by the lack of viruses known to infect nematodes. From wild isolates of C.(More)
Because of the constant threat posed by emerging infectious diseases and the limitations of existing approaches used to identify new pathogens, there is a great demand for new technological methods for viral discovery. We describe herein a DNA microarray-based platform for novel virus identification and characterization. Central to this approach was a DNA(More)
Every graph can be decomposed into a tree structure plus a set of remaining edges. We describe a visualization technique that displays the tree structure as a Treemap and the remaining edges as curved links overlaid on the Treemap. Link curves are designed to show where the link starts and where it ends without requiring an explicit arrow that would clutter(More)
—Large blackouts are typically caused by cascading failure propagating through a power system by means of a variety of processes. Because of the wide range of time scales, multiple interacting processes, and the huge number of possible interactions, the simulation and analysis of cascading blackouts is extremely complicated. This paper defines cascading(More)